U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Synpo2l synaptopodin 2-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 305675, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Synpo2lprovided by RGD
Official Full Name
synaptopodin 2-likeprovided by RGD
Primary source
RGD:1565434
See related
EnsemblRapid:ENSRNOG00000008949 AllianceGenome:RGD:1565434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565434
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Predicted to be active in Z disc; actin cytoskeleton; and nucleus. Orthologous to human SYNPO2L (synaptopodin 2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 261.5) and Heart (RPKM 175.2) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Synpo2l in Genome Data Viewer
Location:
15p16
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3681224..3690673)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3631974..3641429)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4064706..4074151)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA51 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene myozenin 1 Neighboring gene ubiquitin specific peptidase 54 Neighboring gene nucleolin, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart. van Eldik W, et al. PLoS One, 2017. PMID 29206857, Free PMC Article
  2. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Beqqali A, et al. J Cell Sci, 2010 Apr 1. PMID 20215401
  3. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sarcomere organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
synaptopodin 2-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305138.3 → NP_001292067.1  synaptopodin 2-like protein isoform 1

    See identical proteins and their annotated locations for NP_001292067.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KKP4, D3ZZ68
    Related
    ENSRNOP00000011956.5, ENSRNOT00000011956.6
    Conserved Domains (1) summary
    cd00992
    Location:6 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001305139.3 → NP_001292068.1  synaptopodin 2-like protein isoform 2

    See identical proteins and their annotated locations for NP_001292068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region, contains an alternate 5'-terminal exon, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I5ZSY9
    Conserved Domains (1) summary
    PHA03247
    Location:194 → 391
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    3681224..3690673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093230.2 → XP_038949158.1  synaptopodin 2-like protein isoform X1

    UniProtKB/TrEMBL
    A6KKP5
    Conserved Domains (1) summary
    PHA03247
    Location:127 → 324
    PHA03247; large tegument protein UL36; Provisional

  2. XM_039093229.2 → XP_038949157.1  synaptopodin 2-like protein isoform X1

    UniProtKB/TrEMBL
    A6KKP5
    Conserved Domains (1) summary
    PHA03247
    Location:127 → 324
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools