Pcgf3 polycomb group ring finger 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcgf3provided by RGD
Official Full Name: polycomb group ring finger 3provided by RGD
Primary source: RGD:1311479
See related: AllianceGenome:RGD:1311479
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnf3
Summary: Predicted to enable histone H2AK119 ubiquitin ligase activity. Predicted to be involved in random inactivation of X chromosome and regulation of transcription by RNA polymerase II. Predicted to be located in X chromosome and nucleoplasm. Predicted to be part of PRC1 complex. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Expression: Biased expression in Thymus (RPKM 102.3), Lung (RPKM 93.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1381976..1436709, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1237594..1291717, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2247805..2297155, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D14Got2 (e-PCR)
- UniSTS:114570

AU049720 (e-PCR)
- UniSTS:146166

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AK119 ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in random inactivation of X chromosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in X chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycomb group RING finger protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107245.2 → NP_001100715.2 polycomb group RING finger protein 3

See identical proteins and their annotated locations for NP_001100715.2

Status: PROVISIONAL

Source sequence(s)

BC167000

UniProtKB/TrEMBL

B2RZ26, F7EV63

Conserved Domains (2) summary

cd16735
Location:14 → 60

RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

cd17083
Location:153 → 235

RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins