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Ahsa2 activator of HSP90 ATPase homolog 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305577, updated on 4-Jan-2025

Summary

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Official Symbol
Ahsa2provided by RGD
Official Full Name
activator of HSP90 ATPase homolog 2provided by RGD
Primary source
RGD:1307171
See related
EnsemblRapid:ENSRNOG00000052142 AllianceGenome:RGD:1307171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 122.8), Thymus (RPKM 122.1) and 9 other tissues See more
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Genomic context

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See Ahsa2 in Genome Data Viewer
Location:
14q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101677447..101688706, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (97476304..97485725, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (108262795..108274000, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ubiquitin specific peptidase 34 Neighboring gene telomerase RNA component interacting Rnase like 1 Neighboring gene uncharacterized LOC108352815 Neighboring gene similar to human chromosome 2 open reading frame 74 Neighboring gene deoxycytidine kinase, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
activator of 90 kDa heat shock protein ATPase homolog 2
Names
AHA1, activator of heat shock protein ATPase 2
AHA1, activator of heat shock protein ATPase homolog 2
activator of heat shock protein ATPase homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401431.1 → NP_001388360.1  activator of 90 kDa heat shock protein ATPase homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2K7W5, A0A8I6ACS3
    Related
    ENSRNOP00000074374.1, ENSRNOT00000084642.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    101677447..101688706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251541.5 → XP_006251603.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_006251603.1

    UniProtKB/TrEMBL
    A0A8I6ACS3
    Conserved Domains (2) summary
    cd08892
    Location:154 → 273
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:1 → 110
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

  2. XM_006251539.5 → XP_006251601.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACS3
    Related
    ENSRNOP00000091962.2, ENSRNOT00000095424.2
    Conserved Domains (3) summary
    cd08892
    Location:239 → 358
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:67 → 195
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    COG5580
    Location:20 → 358
    COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

  3. XM_063273267.1 → XP_063129337.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

  4. XM_006251542.5 → XP_006251604.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_006251604.1

    UniProtKB/TrEMBL
    A0A8I6ACS3
    Conserved Domains (2) summary
    cd08892
    Location:154 → 273
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:1 → 110
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

RNA

  1. XR_005492978.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107241.1: Suppressed sequence

    Description
    NM_001107241.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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