tcf7l1b transcription factor 7 like 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcf7l1bprovided by ZNC
Official Full Name: transcription factor 7 like 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991110-10
See related: Ensembl:ENSDARG00000007369 AllianceGenome:ZFIN:ZDB-GENE-991110-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tcf3b; TCF-3-B
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell proliferation in dorsal spinal cord; endothelial cell fate specification; and nervous system development. Predicted to be located in chromatin. Predicted to be part of beta-catenin-TCF complex. Is expressed in nervous system; optic vesicle; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (52107747..52230115, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (52121218..52243586, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results argue that during anterior-posterior patterning of the mesoderm Tcf7l1 proteins are cell autonomously required to limit Wnt signaling
Title: Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish.
Results indicate that Tcf7l1 plays an important role in spinal cord progenitor maintenance
Title: Tcf7l1 is required for spinal cord progenitor maintenance.

Submit: New GeneRIF Correction

General gene information

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Markers

G45192 (e-PCR)
- UniSTS:105994

z28258 (e-PCR), detects polymorphism
- UniSTS:238947

G46120 (e-PCR)
- UniSTS:106922

tcf3b (e-PCR)
- UniSTS:205495

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell proliferation in dorsal spinal cord	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endothelial cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
involved_in generation of neurons	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within generation of neurons	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rostrocaudal neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within spinal cord dorsal/ventral patterning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor 7-like 1-B

Names: HMG box transcription factor 3-B; transcription factor 7-like 1b (T-cell specific, HMG-box); transcription factor tcf3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131296.2 → NP_571371.2 transcription factor 7-like 1-B

Status: VALIDATED

Source sequence(s)

BX005248, CU570784

UniProtKB/Swiss-Prot

Q800Q5

UniProtKB/TrEMBL

A0A8M1PBS1, F1R336

Related

ENSDARP00000051824.5, ENSDART00000051825.7

Conserved Domains (2) summary

cd01388
Location:325 → 396

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 231

CTNNB1_binding; N-terminal CTNNB1 binding