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Pik3ip1 phosphoinositide-3-kinase interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305472, updated on 27-Nov-2024

Summary

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Official Symbol
Pik3ip1provided by RGD
Official Full Name
phosphoinositide-3-kinase interacting protein 1provided by RGD
Primary source
RGD:1311203
See related
EnsemblRapid:ENSRNOG00000018859 AllianceGenome:RGD:1311203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
zgc:66482; RGD1311203
Summary
Predicted to enable endopeptidase activity; phosphatidylinositol 3-kinase inhibitor activity; and signaling receptor binding activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human PIK3IP1 (phosphoinositide-3-kinase interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 185.5), Muscle (RPKM 130.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pik3ip1 in Genome Data Viewer
Location:
14q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82428315..82440261)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78204668..78216616)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83559397..83572481)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene LIM domain kinase 2 Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L7, pseudogene 1 Neighboring gene ring finger protein 185 Neighboring gene uncharacterized LOC134481864

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway. Liu X, et al. Bioengineered, 2022 Jan. PMID 35000528, Free PMC Article
  2. PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein. Zhu Z, et al. Biochem Biophys Res Commun, 2007 Jun 22. PMID 17475214, Free PMC Article
  3. PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma. He X, et al. Cancer Res, 2008 Jul 15. PMID 18632611, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
    Title: Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol 3-kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol 3-kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol 3-kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide-3-kinase-interacting protein 1
Names
HGFL protein
kringle domain-containing protein HGFL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395158.1 → NP_001382087.1  phosphoinositide-3-kinase-interacting protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q56A20
    UniProtKB/TrEMBL
    A6IK99, G3V9P1
    Related
    ENSRNOP00000095057.2, ENSRNOT00000112805.2
    Conserved Domains (1) summary
    smart00130
    Location:23 → 103
    KR; Kringle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    82428315..82440261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092006.2 → XP_038947934.1  phosphoinositide-3-kinase-interacting protein 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017453.1: Suppressed sequence

    Description
    NM_001017453.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56A20.2 GenPept UniProtKB/Swiss-Prot:Q56A20

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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