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Pi4k2b phosphatidylinositol 4-kinase type 2 beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 305419, updated on 27-Nov-2024

Summary

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Official Symbol
Pi4k2bprovided by RGD
Official Full Name
phosphatidylinositol 4-kinase type 2 betaprovided by RGD
Primary source
RGD:1359515
See related
EnsemblRapid:ENSRNOG00000003924 AllianceGenome:RGD:1359515
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in Golgi organization; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in bounding membrane of organelle; cytosol; and endoplasmic reticulum membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 220.0), Testes (RPKM 195.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pi4k2b in Genome Data Viewer
Location:
14q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (62434589..62461507, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (58221790..58248716, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (60567968..60594821, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 4 Neighboring gene zinc finger CCHC-type containing 4 Neighboring gene uncharacterized LOC134481754 Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene uncharacterized LOC102552822

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment. Kapp-Barnea Y, et al. Mol Biol Cell, 2006 Sep. PMID 16837555, Free PMC Article
  2. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. Balla A, et al. J Biol Chem, 2002 May 31. PMID 11923287
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate a novel role for NCS-1 and PI4Kbeta in regulating ERK1/2 signaling and inflammatory reactions in mast cells.
    Title: Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94512

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase type 2-beta
Names
phosphatidylinositol 4-kinase type II-beta
NP_001005883.1
XP_038947867.1
XP_038947868.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005883.1 → NP_001005883.1  phosphatidylinositol 4-kinase type 2-beta

    See identical proteins and their annotated locations for NP_001005883.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083668
    UniProtKB/Swiss-Prot
    Q5XIL2
    UniProtKB/TrEMBL
    A6IJH1
    Related
    ENSRNOP00000103557.1, ENSRNOT00000171326.1
    Conserved Domains (1) summary
    pfam00454
    Location:125 → 423
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    62434589..62461507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091939.2 → XP_038947867.1  phosphatidylinositol 4-kinase type 2-beta isoform X1

    Conserved Domains (1) summary
    pfam00454
    Location:125 → 346
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

  2. XM_039091940.2 → XP_038947868.1  phosphatidylinositol 4-kinase type 2-beta isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:125 → 299
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIL2.1 GenPept UniProtKB/Swiss-Prot:Q5XIL2

Gene LinkOut

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