U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slain2 SLAIN motif family, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305310, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Slain2provided by RGD
Official Full Name
SLAIN motif family, member 2provided by RGD
Primary source
RGD:1311593
See related
EnsemblRapid:ENSRNOG00000002271 AllianceGenome:RGD:1311593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311593
Summary
Predicted to be involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Predicted to be located in centrosome and cytosol. Predicted to colocalize with microtubule plus-end. Orthologous to human SLAIN2 (SLAIN motif family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 335.6), Muscle (RPKM 244.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slain2 in Genome Data Viewer
Location:
14p11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35590050..35667734, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35236034..35314186, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (37802347..37880571, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transfer RNA histidin (anticodon AUG) 2 Neighboring gene solute carrier family 10, member 4 Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene tec protein tyrosine kinase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. van der Vaart B, et al. J Cell Biol, 2011 Jun 13. PMID 21646404, Free PMC Article
  2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SLAIN motif-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107214.1 → NP_001100684.1  SLAIN motif-containing protein 2

    See identical proteins and their annotated locations for NP_001100684.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473981
    UniProtKB/TrEMBL
    A6JD58
    Conserved Domains (1) summary
    pfam15301
    Location:130 → 607
    SLAIN; SLAIN motif-containing family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    35590050..35667734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273083.1 → XP_063129153.1  SLAIN motif-containing protein 2 isoform X4

  2. XM_017599185.3 → XP_017454674.1  SLAIN motif-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15301
    Location:9 → 486
    SLAIN; SLAIN motif-containing family

  3. XM_006250899.5 → XP_006250961.1  SLAIN motif-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIE0
    Related
    ENSRNOP00000092872.1, ENSRNOT00000119145.2
    Conserved Domains (1) summary
    pfam15301
    Location:130 → 581
    SLAIN; SLAIN motif-containing family

  4. XM_006250898.5 → XP_006250960.1  SLAIN motif-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    G3V6A2
    Related
    ENSRNOP00000003087.6, ENSRNOT00000003087.7
    Conserved Domains (1) summary
    pfam15301
    Location:130 → 608
    SLAIN; SLAIN motif-containing family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools