Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abl2provided by RGD
Official Full Name: ABL proto-oncogene 2, non-receptor tyrosine kinaseprovided by RGD
Primary source: RGD:1590898
See related: EnsemblRapid:ENSRNOG00000004305 AllianceGenome:RGD:1590898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Arg; Abll
Summary: Predicted to enable metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of establishment of T cell polarity; and synapse maturation. Predicted to act upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Predicted to be located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 64.3), Brain (RPKM 56.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (71223902..71319770)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (68673702..68770846)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (74154533..74333244)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1-42 Peptides.
Title: Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1-42 Peptides.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA925877 (e-PCR)
- UniSTS:248586

RH132874 (e-PCR)
- UniSTS:216157

D13Got50 (e-PCR)
- UniSTS:115346

BI282517 (e-PCR)
- UniSTS:249808

BI274170 (e-PCR)
- UniSTS:249049

AA801206 (e-PCR)
- UniSTS:261612

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DN4 thymocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aggressive behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory behavior	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration, cell extension	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase ABL2

Names: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abl1-related gene product; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

NP_001382059.1

EC 2.7.10.1

XP_006250109.1

EC 2.7.10.1

XP_006250111.1

EC 2.7.10.1

XP_006250113.1

EC 2.7.10.1

XP_006250114.1

EC 2.7.10.1

XP_006250115.1

EC 2.7.10.1

XP_006250116.1

EC 2.7.10.1

XP_006250117.1

EC 2.7.10.1

XP_063128394.1

EC 2.7.10.1

XP_063128395.1

EC 2.7.10.1

XP_063128397.1

EC 2.7.10.1

XP_063128398.1

EC 2.7.10.1

XP_063128399.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395130.2 → NP_001382059.1 tyrosine-protein kinase ABL2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ID14, F1M0N1

Related

ENSRNOP00000107477.1, ENSRNOT00000171907.1

Conserved Domains (4) summary

smart00808
Location:1063 → 1182

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

71223902..71319770

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272325.1 → XP_063128395.1 tyrosine-protein kinase ABL2 isoform X4

UniProtKB/TrEMBL

A6ID14, F1M0N1

Related

ENSRNOP00000096793.2, ENSRNOT00000102486.2
XM_006250052.4 → XP_006250114.1 tyrosine-protein kinase ABL2 isoform X7

UniProtKB/TrEMBL

A0A8I5ZY28, A6ID14, F1M0N1

Related

ENSRNOP00000082517.1, ENSRNOT00000104990.2

Conserved Domains (5) summary

smart00808
Location:959 → 1078

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:288 → 539

STYKc; Protein kinase; unclassified specificity

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006250047.4 → XP_006250109.1 tyrosine-protein kinase ABL2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZXU9, A6ID14, F1M0N1

Conserved Domains (5) summary

smart00808
Location:1062 → 1181

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:288 → 539

STYKc; Protein kinase; unclassified specificity

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006250051.4 → XP_006250113.1 tyrosine-protein kinase ABL2 isoform X5

UniProtKB/TrEMBL

A0A8I6GM88, A6ID14, F1M0N1

Related

ENSRNOP00000056281.3, ENSRNOT00000059524.5

Conserved Domains (5) summary

smart00808
Location:1041 → 1160

FABD; F-actin binding domain (FABD)

cd09935
Location:148 → 241

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:90 → 143

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:267 → 518

STYKc; Protein kinase; unclassified specificity

cd05052
Location:260 → 522

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006250053.5 → XP_006250115.1 tyrosine-protein kinase ABL2 isoform X8

UniProtKB/TrEMBL

A6ID14, F1M0N1

Conserved Domains (5) summary

smart00808
Location:958 → 1077

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:288 → 539

STYKc; Protein kinase; unclassified specificity

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006250055.5 → XP_006250117.1 tyrosine-protein kinase ABL2 isoform X10

UniProtKB/TrEMBL

A6ID14, F1M0N1

Conserved Domains (5) summary

smart00808
Location:937 → 1056

FABD; F-actin binding domain (FABD)

cd09935
Location:148 → 241

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:90 → 143

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:267 → 518

STYKc; Protein kinase; unclassified specificity

cd05052
Location:260 → 522

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_063272327.1 → XP_063128397.1 tyrosine-protein kinase ABL2 isoform X6

UniProtKB/TrEMBL

A6ID14, F1M0N1

Related

ENSRNOP00000082815.2, ENSRNOT00000106669.2
XM_063272328.1 → XP_063128398.1 tyrosine-protein kinase ABL2 isoform X11
XM_063272324.1 → XP_063128394.1 tyrosine-protein kinase ABL2 isoform X2

UniProtKB/TrEMBL

A6ID14, F1M0N1

Related

ENSRNOP00000102900.1, ENSRNOT00000144767.1
XM_006250049.5 → XP_006250111.1 tyrosine-protein kinase ABL2 isoform X3

UniProtKB/TrEMBL

A6ID14, F1M0N1

Conserved Domains (5) summary

smart00808
Location:1047 → 1166

FABD; F-actin binding domain (FABD)

cd09935
Location:154 → 247

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:96 → 149

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:273 → 524

STYKc; Protein kinase; unclassified specificity

cd05052
Location:266 → 528

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006250054.5 → XP_006250116.1 tyrosine-protein kinase ABL2 isoform X9

UniProtKB/TrEMBL

A6ID14, F1M0N1

Conserved Domains (5) summary

smart00808
Location:943 → 1062

FABD; F-actin binding domain (FABD)

cd09935
Location:154 → 247

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:96 → 149

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:273 → 524

STYKc; Protein kinase; unclassified specificity

cd05052
Location:266 → 528

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_063272329.1 → XP_063128399.1 tyrosine-protein kinase ABL2 isoform X12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107186.1: Suppressed sequence

Description

NM_001107186.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.