Ipo9 importin 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ipo9provided by RGD
Official Full Name: importin 9provided by RGD
Primary source: RGD:1310537
See related: EnsemblRapid:ENSRNOG00000007418 AllianceGenome:RGD:1310537
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone binding activity; histone chaperone activity; and nuclear import signal receptor activity. Predicted to be involved in proteasome localization and protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nuclear envelope. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 155.5), Spleen (RPKM 135.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (49362244..49414477, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (46810460..46862694, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (52203384..52256196, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe the structure of the rat importin 9 gene, together with its transcripts and the encoded protein with its putative functional domains.
Title: Cloning and characterization of rat importin 9: implication for its neuronal function.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteasome localization	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: importin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107180.1 → NP_001100650.1 importin-9

See identical proteins and their annotated locations for NP_001100650.1

Status: PROVISIONAL

Source sequence(s)

CH473958

UniProtKB/TrEMBL

A6ICF3, D4A857

Related

ENSRNOP00000011105.6, ENSRNOT00000011105.7

Conserved Domains (1) summary

COG5657
Location:34 → 812

CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

49362244..49414477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272310.1 → XP_063128380.1 importin-9 isoform X2
XM_008769563.4 → XP_008767785.1 importin-9 isoform X1

UniProtKB/TrEMBL

D4A857

Related

ENSRNOP00000100509.1, ENSRNOT00000145946.1

Conserved Domains (1) summary

COG5657
Location:3 → 776

CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
XM_039090722.2 → XP_038946650.1 importin-9 isoform X2

UniProtKB/TrEMBL

D4A857

Conserved Domains (1) summary

COG5656
Location:192 → 749

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
XM_063272309.1 → XP_063128379.1 importin-9 isoform X2
XM_063272308.1 → XP_063128378.1 importin-9 isoform X2