rx2 retinal homeobox gene 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rx2provided by ZNC
Official Full Name: retinal homeobox gene 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-237
See related: Ensembl:ENSDARG00000040321 AllianceGenome:ZFIN:ZDB-GENE-990415-237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within camera-type eye photoreceptor cell differentiation. Predicted to be located in nucleus. Is expressed in eye; immature eye; optic primordium; and presumptive diencephalon. Human ortholog(s) of this gene implicated in age related macular degeneration 6; cone-rod dystrophy 11; isolated microphthalmia 3; and retinitis pigmentosa. Orthologous to several human genes including RAX2 (retina and anterior neural fold homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (55833425..55861351, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (55707831..55737506, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinal homeobox protein Rx2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131226.2 → NP_571301.2 retinal homeobox protein Rx2

Status: VALIDATED

Source sequence(s)

CU855756, EH590819

UniProtKB/Swiss-Prot

O42357

UniProtKB/TrEMBL

A0A8M1PBI7, F1QNV0

Related

ENSDARP00000059002.5, ENSDART00000059003.6

Conserved Domains (2) summary

pfam00046
Location:139 → 191

Homeobox; Homeobox domain

pfam03826
Location:302 → 316

OAR; OAR domain