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Hook2 hook microtubule-tethering protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304669, updated on 4-Jan-2025

Summary

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Official Symbol
Hook2provided by RGD
Official Full Name
hook microtubule-tethering protein 2provided by RGD
Primary source
RGD:1310171
See related
EnsemblRapid:ENSRNOG00000003682 AllianceGenome:RGD:1310171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 131.8), Testes (RPKM 119.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hook2 in Genome Data Viewer
Location:
19q11
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40056732..40075027, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23151869..23170139, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26106713..26119353)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene bestrophin 2 Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene peroxiredoxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. Szebenyi G, et al. Traffic, 2007 Jan. PMID 17140400
  2. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Hook homolog 2
Names
hook homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100562.1 → NP_001094032.1  protein Hook homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC099235, BQ203898, CB548211, CB696289, CB785578
    UniProtKB/TrEMBL
    E9PTX3
    Conserved Domains (2) summary
    pfam05622
    Location:8 → 706
    HOOK; HOOK protein
    pfam10267
    Location:260 → 344
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. NM_001415053.1 → NP_001401982.1  protein Hook homolog 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IY41, E9PTX3
    Related
    ENSRNOP00000033999.5, ENSRNOT00000035987.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40056732..40075027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097685.2 → XP_038953613.1  protein Hook homolog 2 isoform X3

    UniProtKB/TrEMBL
    E9PTX3
    Conserved Domains (2) summary
    pfam05622
    Location:215 → 737
    HOOK; HOOK protein
    pfam19047
    Location:52 → 193
    HOOK_N; HOOK domain

  2. XM_039097684.2 → XP_038953612.1  protein Hook homolog 2 isoform X2

    UniProtKB/TrEMBL
    E9PTX3
    Related
    ENSRNOP00000108421.1, ENSRNOT00000128519.1
    Conserved Domains (2) summary
    pfam05622
    Location:215 → 738
    HOOK; HOOK protein
    pfam19047
    Location:52 → 193
    HOOK_N; HOOK domain

  3. XM_063277971.1 → XP_063134041.1  protein Hook homolog 2 isoform X7

    UniProtKB/TrEMBL
    Q4FZR1

  4. XM_039097683.2 → XP_038953611.1  protein Hook homolog 2 isoform X1

    UniProtKB/TrEMBL
    E9PTX3
    Conserved Domains (2) summary
    pfam05622
    Location:179 → 768
    HOOK; HOOK protein
    pfam19047
    Location:7 → 157
    HOOK_N; HOOK domain

  5. XM_006255258.5 → XP_006255320.1  protein Hook homolog 2 isoform X4

    UniProtKB/TrEMBL
    E9PTX3
    Conserved Domains (2) summary
    pfam05622
    Location:8 → 703
    HOOK; HOOK protein
    pfam10267
    Location:260 → 344
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  6. XM_063277969.1 → XP_063134039.1  protein Hook homolog 2 isoform X5

    UniProtKB/TrEMBL
    E9PTX3

  7. XM_039097686.2 → XP_038953614.1  protein Hook homolog 2 isoform X8

    UniProtKB/TrEMBL
    Q4FZR1
    Conserved Domains (2) summary
    pfam05622
    Location:110 → 632
    HOOK; HOOK protein
    pfam19047
    Location:60 → 88
    HOOK_N; HOOK domain

  8. XM_063277972.1 → XP_063134042.1  protein Hook homolog 2 isoform X7

    UniProtKB/TrEMBL
    Q4FZR1

  9. XM_063277970.1 → XP_063134040.1  protein Hook homolog 2 isoform X6

    Related
    ENSRNOP00000103421.1, ENSRNOT00000133566.1

RNA

  1. XR_010059990.1 RNA Sequence

  2. XR_010059991.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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