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Klf1 KLF transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304666, updated on 27-Nov-2024

Summary

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Official Symbol
Klf1provided by RGD
Official Full Name
KLF transcription factor 1provided by RGD
Primary source
RGD:1309398
See related
EnsemblRapid:ENSRNOG00000003443 AllianceGenome:RGD:1309398
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin binding activity. Involved in cellular response to peptide and maternal process involved in female pregnancy. Predicted to be located in chromatin and nucleoplasm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (KLF transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 271.7) and Lung (RPKM 11.0) See more
Orthologs
human mouse all
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Genomic context

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See Klf1 in Genome Data Viewer
Location:
19q11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40155476..40158651, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23250627..23253802, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26016289..26019557)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene microRNA 3550 Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Qian Z, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12417757, Free PMC Article
  2. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Drissen R, et al. Genes Dev, 2004 Oct 15. PMID 15489291, Free PMC Article
  3. A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia. Arnaud L, et al. Am J Hum Genet, 2010 Nov 12. PMID 21055716, Free PMC Article
  4. Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model. Heruth DP, et al. Genomics, 2010 Nov. PMID 20691777, Free PMC Article
  5. Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Borg J, et al. Nat Genet, 2010 Sep. PMID 20676099, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Krueppel-like factor 1
Names
Kruppel like factor 1
Kruppel-like factor 1 (erythroid)
erythroid Kruppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107164.1 → NP_001100634.1  Krueppel-like factor 1

    See identical proteins and their annotated locations for NP_001100634.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IY63, B0BNN2
    Related
    ENSRNOP00000004601.6, ENSRNOT00000004601.7
    Conserved Domains (6) summary
    COG5048
    Location:297 → 375
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:293 → 317
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain
    pfam16832
    Location:40 → 65
    EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
    pfam16833
    Location:81 → 103
    EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40155476..40158651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255254.5 → XP_006255316.1  Krueppel-like factor 1 isoform X1

    UniProtKB/TrEMBL
    B0BNN2
    Conserved Domains (6) summary
    COG5048
    Location:297 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:293 → 317
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain
    pfam16832
    Location:40 → 65
    EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
    pfam16833
    Location:81 → 103
    EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2
Nucleotide Protein Strain
Heading Accession and Version

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