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rxrga retinoid x receptor, gamma a [ Danio rerio (zebrafish) ]

Gene ID: 30464, updated on 9-Dec-2024

Summary

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Official Symbol
rxrgaprovided by ZNC
Official Full Name
retinoid x receptor, gamma aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-36
See related
Ensembl:ENSDARG00000005593 AllianceGenome:ZFIN:ZDB-GENE-980526-36
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RXR; rxra; rxrg; NR2B1
Summary
Enables nuclear receptor activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within intracellular receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including mesoderm; neural rod; pharyngeal arch; retina; and tail bud. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: suggests misassembly
Orthologs
all
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Genomic context

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See rxrga in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20725684..20776841)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21067712..21118926)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 12 Neighboring gene uncharacterized LOC110438025 Neighboring gene proteoglycan 4a Neighboring gene translocated promoter region a, nuclear basket protein Neighboring gene odr-4 GPCR localization factor homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt. Walker SE, et al. Neural Regen Res, 2018 Jun. PMID 29926831, Free PMC Article
  2. Estrogenic effects of nonylphenol and octylphenol isomers in vitro by recombinant yeast assay (RYA) and in vivo with early life stages of zebrafish. Puy-Azurmendi E, et al. Sci Total Environ, 2014 Jan 1. PMID 23892017
  3. The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates. Gauchat D, et al. Dev Biol, 2004 Nov 1. PMID 15464576
  4. Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development. Hale LA, et al. Gene Expr Patterns, 2006 Jun. PMID 16455309
  5. Retinoid requirements in the reproduction of zebrafish. Alsop D, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18158153

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
    Title: Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
  2. The RA receptors RXR gamma and RAR alpha-b are expressed in patterns consistent with mediating the effects of RA on photoreceptors.
    Title: Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
  
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinoic acid receptor RXR-gamma-A
Names
NR2B3
nr2b3a
nuclear receptor subfamily 2 group B member 3-A
retinoic acid receptor RXR-alpha
retinoid X receptor alpha
retinoid X receptor gamma-A
retinoid receptor-alpha
retinoid x receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131217.4 → NP_571292.3  retinoic acid receptor RXR-gamma-A

    Status: VALIDATED

    Source sequence(s)
    BC059576, CABZ01020455, CABZ01063427, CABZ01063428, CU855759, EH435141, FO681336
    UniProtKB/Swiss-Prot
    Q6PBU9, Q90416
    UniProtKB/TrEMBL
    A0A8N1TSS1
    Related
    ENSDART00000021168.9
    Conserved Domains (3) summary
    cd06943
    Location:211 → 419
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:115 → 191
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:40 → 111
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    20725684..20776841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90416.2 GenPept UniProtKB/Swiss-Prot:Q90416

Gene LinkOut

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