exorh extra-ocular rhodopsin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: exorhprovided by ZNC
Official Full Name: extra-ocular rhodopsinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991229-12
See related: Ensembl:ENSDARG00000103574 Ensembl:ENSDARG00000111860 AllianceGenome:ZFIN:ZDB-GENE-991229-12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ex; ExR; exo-rod
Summary: Enables G protein-coupled photoreceptor activity and retinal binding activity. Acts upstream of or within absorption of visible light and circadian regulation of gene expression. Predicted to be located in membrane. Is expressed in several structures, including digestive system; heart; nervous system; testis; and yolk. [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (54302693..54304381, complement)
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003337228.1 (123..1639, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (54189853..54191541, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003337228.1 (123..1639, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland.
Title: Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland.
This work identifies novel roles for Exorh and Per3, and gives insight into potential interactions between the sensory and circadian systems within the pineal.
Title: Novel functions for Period 3 and Exo-rhodopsin in rhythmic transcription and melatonin biosynthesis within the zebrafish pineal organ.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled photoreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables photoreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info
enables retinal binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within absorption of visible light	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of visible light	IDA Inferred from Direct Assay more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phototransduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to light stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: extra-ocular rhodopsin

Names: exo-rhodopsin; exorhodopsin; zfExR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131212.2 → NP_571287.1 extra-ocular rhodopsin

See identical proteins and their annotated locations for NP_571287.1

Status: PROVISIONAL

Source sequence(s)

BC098524

UniProtKB/TrEMBL

Q9PTX9

Related

ENSDARP00000139781.1, ENSDARP00000153318.1, ENSDART00000168791.2, ENSDART00000184177.1

Conserved Domains (3) summary

pfam00001
Location:55 → 306

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam10413
Location:2 → 37

Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin

cl21561
Location:48 → 248

7tm_4; Olfactory receptor