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Hectd4 HECT domain E3 ubiquitin protein ligase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304503, updated on 2-Nov-2024

Summary

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Official Symbol
Hectd4provided by RGD
Official Full Name
HECT domain E3 ubiquitin protein ligase 4provided by RGD
Primary source
RGD:1309762
See related
EnsemblRapid:ENSRNOG00000001352 AllianceGenome:RGD:1309762
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309762
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in glucose homeostasis and glucose metabolic process. Orthologous to human HECTD4 (HECT domain E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 134.0), Brain (RPKM 127.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hectd4 in Genome Data Viewer
Location:
12q16
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40800232..40991584, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35182165..35330935, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40712078..40860930, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene 40S ribosomal protein S27-like Neighboring gene 40S ribosomal protein S20-like Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene ribosomal protein L6 Neighboring gene protein tyrosine phosphatase, non-receptor type 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination. Zhang YY, et al. Mol Neurobiol, 2023 Mar. PMID 36527595
  2. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. Go MJ, et al. J Hum Genet, 2013 Jun. PMID 23575436
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
    Title: The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HECTD4
Names
HECT domain containing E3 ubiquitin protein ligase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    40800232..40991584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089874.2 → XP_038945802.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2413 → 2568
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4033 → 4426
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. XM_039089873.2 → XP_038945801.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2414 → 2569
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4033 → 4426
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. XM_017598533.3 → XP_017454022.2  probable E3 ubiquitin-protein ligase HECTD4 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2398 → 2553
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4018 → 4411
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  4. XM_063271893.1 → XP_063127963.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X7

  5. XM_039089875.2 → XP_038945803.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2412 → 2567
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4032 → 4425
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_039089878.2 → XP_038945806.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2400 → 2555
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4020 → 4413
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. XM_039089877.2 → XP_038945805.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Related
    ENSRNOP00000084673.2, ENSRNOT00000109636.2
    Conserved Domains (2) summary
    cd13735
    Location:2405 → 2560
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4025 → 4418
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  8. XM_039089876.2 → XP_038945804.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2409 → 2564
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4029 → 4422
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  9. XM_039089872.2 → XP_038945800.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZM0
    Conserved Domains (2) summary
    cd13735
    Location:2414 → 2569
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4034 → 4427
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  10. XM_039089879.2 → XP_038945807.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X10

    UniProtKB/TrEMBL
    F1LZX5
    Conserved Domains (2) summary
    cd13735
    Location:1888 → 2043
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:3508 → 3901
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  11. XM_039089880.2 → XP_038945808.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X11

    UniProtKB/TrEMBL
    F1LZX5
    Conserved Domains (2) summary
    cd13735
    Location:1370 → 1525
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:2990 → 3383
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  12. XM_039089882.1 → XP_038945810.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X12

    Conserved Domains (2) summary
    cd13735
    Location:930 → 1085
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:2550 → 2943
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. XR_010056783.1 RNA Sequence

  2. XR_010056782.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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