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Castor2 cytosolic arginine sensor for mTORC1 subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304410, updated on 9-Dec-2024

Summary

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Official Symbol
Castor2provided by RGD
Official Full Name
cytosolic arginine sensor for mTORC1 subunit 2provided by RGD
Primary source
RGD:1304672
See related
EnsemblRapid:ENSRNOG00000067286 AllianceGenome:RGD:1304672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gats; Gatsl2
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to several human genes including CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 55.3), Brain (RPKM 55.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Castor2 in Genome Data Viewer
Location:
12q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (28213927..28256593, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22577504..22620182, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25595800..25638806, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene GTF2I repeat domain containing 2 Neighboring gene uncharacterized LOC134481282 Neighboring gene RCC1 like Neighboring gene uncharacterized LOC102553721 Neighboring gene uncharacterized LOC134481174 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CASTORing New Light on Amino Acid Sensing. Hallett JEH, et al. Cell, 2016 Mar 24. PMID 27015302
  2. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Chantranupong L, et al. Cell, 2016 Mar 24. PMID 26972053, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables arginine binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic arginine sensor for mTORC1 subunit 2
Names
GATS protein-like 2
GATS-like protein 2
opposite strand transcription unit to Stag3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100561.2 → NP_001094031.1  cytosolic arginine sensor for mTORC1 subunit 2

    See identical proteins and their annotated locations for NP_001094031.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J0K8, G3V665
    Related
    ENSRNOP00000095312.1, ENSRNOT00000110618.2
    Conserved Domains (2) summary
    pfam13840
    Location:260 → 322
    ACT_7; ACT domain
    pfam18700
    Location:9 → 69
    Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    28213927..28256593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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