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Foxk1 forkhead box K1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304298, updated on 27-Nov-2024

Summary

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Official Symbol
Foxk1provided by RGD
Official Full Name
forkhead box K1provided by RGD
Primary source
RGD:1309643
See related
EnsemblRapid:ENSRNOG00000001104 AllianceGenome:RGD:1309643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309643
Summary
Predicted to enable 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Orthologous to human FOXK1 (forkhead box K1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 37.0), Adrenal (RPKM 35.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Foxk1 in Genome Data Viewer
Location:
12q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17223599..17288564, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (12110119..12175089, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14183436..14244634, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene Rap associating with DIL domain Neighboring gene poly(A) polymerase beta Neighboring gene uncharacterized LOC120095892 Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene sidekick cell adhesion molecule 1 Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transient expression of a winged-helix protein, MNF-beta, during myogenesis. Yang Q, et al. Mol Cell Biol, 1997 Sep. PMID 9271401, Free PMC Article
  2. Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF. Freddie CT, et al. Nucleic Acids Res, 2007. PMID 17670796, Free PMC Article
  3. The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. Yang Q, et al. Biochem J, 2000 Jan 15. PMID 10620510, Free PMC Article
  4. FOXK1 and FOXK2 regulate aerobic glycolysis. Sukonina V, et al. Nature, 2019 Feb. PMID 30700909
  5. mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. He L, et al. Mol Cell, 2018 Jun 7. PMID 29861159, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of canonical glycolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
forkhead box protein K1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037219.2 → NP_001032296.2  forkhead box protein K1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZU55
    Related
    ENSRNOP00000001466.6, ENSRNOT00000001466.8
    Conserved Domains (3) summary
    COG1716
    Location:88 → 190
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:96 → 189
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:291 → 377
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    17223599..17288564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089368.2 → XP_038945296.1  forkhead box protein K1 isoform X1

    Conserved Domains (1) summary
    cd20054
    Location:72 → 172
    FH_FOXK1; Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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