U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tecpr1 tectonin beta-propeller repeat containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304285, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tecpr1provided by RGD
Official Full Name
tectonin beta-propeller repeat containing 1provided by RGD
Primary source
RGD:1306873
See related
EnsemblRapid:ENSRNOG00000001010 AllianceGenome:RGD:1306873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306873
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagosome maturation and regulation of autophagosome maturation. Predicted to be located in nucleoplasm. Predicted to be active in autophagosome membrane and lysosomal membrane. Orthologous to human TECPR1 (tectonin beta-propeller repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 82.4), Lung (RPKM 78.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tecpr1 in Genome Data Viewer
Location:
12p11
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15504456..15534541)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10391587..10420462)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12374132..12403382)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 5 Neighboring gene uncharacterized LOC102554669 Neighboring gene brain protein I3 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene lemur tyrosine kinase 2 Neighboring gene elongation factor 1-gamma-like Neighboring gene oncomodulin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Chen D, et al. Mol Cell, 2012 Mar 9. PMID 22342342, Free PMC Article
  2. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Ogawa M, et al. Cell Host Microbe, 2011 May 19. PMID 21575909
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC124730

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tectonin beta-propeller repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037191.1 → NP_001032268.1  tectonin beta-propeller repeat-containing protein 1

    See identical proteins and their annotated locations for NP_001032268.1

    Status: PROVISIONAL

    Source sequence(s)
    BC103478
    UniProtKB/Swiss-Prot
    Q3ZBA0
    Conserved Domains (6) summary
    smart00694
    Location:893 → 926
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64 → 125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:234 → 270
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:609 → 729
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:615 → 721
    PH; PH domain
    pfam06462
    Location:303 → 331
    Hyd_WA; Propeller

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15504456..15534541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598316.3 → XP_017453805.1  tectonin beta-propeller repeat-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3ZBA0
    Related
    ENSRNOP00000001347.5, ENSRNOT00000001347.9
    Conserved Domains (6) summary
    smart00694
    Location:893 → 926
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64 → 125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:234 → 270
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:609 → 729
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:615 → 721
    PH; PH domain
    pfam06462
    Location:303 → 331
    Hyd_WA; Propeller

  2. XM_039089351.2 → XP_038945279.1  tectonin beta-propeller repeat-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A6K1H9
    Conserved Domains (6) summary
    smart00694
    Location:563 → 596
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:491 → 552
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:436 → 469
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:279 → 399
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam06462
    Location:15 → 45
    Hyd_WA; Propeller
    pfam19193
    Location:620 → 767
    Tectonin; Tectonin domain

  3. XM_039089350.2 → XP_038945278.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6K1H9
    Conserved Domains (6) summary
    smart00694
    Location:576 → 609
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:504 → 565
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:449 → 482
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:292 → 412
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam06462
    Location:29 → 58
    Hyd_WA; Propeller
    pfam19193
    Location:633 → 780
    Tectonin; Tectonin domain

RNA

  1. XR_005491622.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZBA0.1 GenPept UniProtKB/Swiss-Prot:Q3ZBA0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools