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Zbtb21 zinc finger and BTB domain containing 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304056, updated on 4-Jan-2025

Summary

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Official Symbol
Zbtb21provided by RGD
Official Full Name
zinc finger and BTB domain containing 21provided by RGD
Primary source
RGD:1310841
See related
EnsemblRapid:ENSRNOG00000001623 AllianceGenome:RGD:1310841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp295; Znf295
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZBTB21 (zinc finger and BTB domain containing 21). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 70.6), Kidney (RPKM 52.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb21 in Genome Data Viewer
Location:
11q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50781697..50796399, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (37312337..37327040, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38442716..38457411, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene uncharacterized LOC134480980 Neighboring gene ribosomal protein S17, pseudogene 5 Neighboring gene leucine rich repeat containing 57, pseudogene 2 Neighboring gene fidgetin-like 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. Wang J, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629158
  2. Nucleosome-interacting proteins regulated by DNA and histone methylation. Bartke T, et al. Cell, 2010 Oct 29. PMID 21029866, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables POZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 21
Names
zinc finger protein 295

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107105.2 → NP_001100575.2  zinc finger and BTB domain-containing protein 21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6IQH9, A6IQI0, D3ZVF2
    Related
    ENSRNOP00000049174.5, ENSRNOT00000041177.7
    Conserved Domains (4) summary
    sd00019
    Location:731 → 751
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:863 → 885
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:568 → 595
    zf_C2H2_6; Zinc Finger domain

  2. NM_001401434.1 → NP_001388363.1  zinc finger and BTB domain-containing protein 21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I5Y585
    Related
    ENSRNOP00000079938.2, ENSRNOT00000116969.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    50781697..50796399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248169.5 → XP_006248231.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_006248231.1

    UniProtKB/TrEMBL
    A0A8I5Y585
    Conserved Domains (6) summary
    sd00017
    Location:571 → 592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:693 → 715
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:764 → 791
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:568 → 621
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  2. XM_006248174.5 → XP_006248236.1  zinc finger and BTB domain-containing protein 21 isoform X2

    See identical proteins and their annotated locations for XP_006248236.1

    UniProtKB/TrEMBL
    A0A8I5ZPL5, A6IQI0
    Conserved Domains (6) summary
    sd00017
    Location:543 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:899 → 919
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:665 → 687
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:736 → 763
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:540 → 593
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  3. XM_006248172.5 → XP_006248234.1  zinc finger and BTB domain-containing protein 21 isoform X2

    See identical proteins and their annotated locations for XP_006248234.1

    UniProtKB/TrEMBL
    A0A8I5ZPL5, A6IQI0
    Conserved Domains (6) summary
    sd00017
    Location:543 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:899 → 919
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:665 → 687
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:736 → 763
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:540 → 593
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  4. XM_039088401.2 → XP_038944329.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y585
    Conserved Domains (6) summary
    sd00017
    Location:571 → 592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:693 → 715
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:764 → 791
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:568 → 621
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  5. XM_039088404.2 → XP_038944332.1  zinc finger and BTB domain-containing protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZPL5, A6IQI0
    Related
    ENSRNOP00000076506.2, ENSRNOT00000102067.2
    Conserved Domains (6) summary
    sd00017
    Location:543 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:899 → 919
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:665 → 687
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:736 → 763
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:540 → 593
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  6. XM_039088400.2 → XP_038944328.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y585
    Conserved Domains (6) summary
    sd00017
    Location:571 → 592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:693 → 715
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:764 → 791
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:568 → 621
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  7. XM_039088405.2 → XP_038944333.1  zinc finger and BTB domain-containing protein 21 isoform X4

    Conserved Domains (4) summary
    sd00017
    Location:265 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:621 → 641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:40 → 80
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:458 → 485
    zf_C2H2_6; Zinc Finger domain

  8. XM_063270576.1 → XP_063126646.1  zinc finger and BTB domain-containing protein 21 isoform X3

    UniProtKB/TrEMBL
    A6IQH9, A6IQI0, D3ZVF2

  9. XM_039088406.2 → XP_038944334.1  zinc finger and BTB domain-containing protein 21 isoform X6

    Conserved Domains (3) summary
    sd00019
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:40 → 81
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:90 → 117
    zf_C2H2_6; Zinc Finger domain

  10. XM_063270579.1 → XP_063126649.1  zinc finger and BTB domain-containing protein 21 isoform X6

    Related
    ENSRNOP00000103395.1, ENSRNOT00000130609.1

  11. XM_063270578.1 → XP_063126648.1  zinc finger and BTB domain-containing protein 21 isoform X5

  12. XM_063270580.1 → XP_063126650.1  zinc finger and BTB domain-containing protein 21 isoform X6

  13. XM_063270577.1 → XP_063126647.1  zinc finger and BTB domain-containing protein 21 isoform X3

    UniProtKB/TrEMBL
    A6IQH9, A6IQI0, D3ZVF2

  14. XM_039088403.2 → XP_038944331.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y585
    Conserved Domains (6) summary
    sd00017
    Location:571 → 592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:693 → 715
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:764 → 791
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:568 → 621
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  15. XM_006248167.3 → XP_006248229.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_006248229.1

    UniProtKB/TrEMBL
    A0A8I5Y585
    Conserved Domains (6) summary
    sd00017
    Location:571 → 592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:693 → 715
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:764 → 791
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:568 → 621
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  16. XM_063270575.1 → XP_063126645.1  zinc finger and BTB domain-containing protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZPL5, A6IQI0
Nucleotide Protein Strain
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