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b2m beta-2-microglobulin [ Danio rerio (zebrafish) ]

Gene ID: 30400, updated on 4-Jan-2025

Summary

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Official Symbol
b2mprovided by ZNC
Official Full Name
beta-2-microglobulinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-88
See related
Ensembl:ENSDARG00000053136 AllianceGenome:ZFIN:ZDB-GENE-980526-88
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bwm; wu:fa94c05; wu:fb10a09
Summary
Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation of peptide antigen via MHC class I and immune response. Predicted to be located in extracellular region. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See b2m in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12793396..12795493, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12794547..12796644, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene helicase (DNA) B Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene high mobility group AT-hook 2 Neighboring gene uncharacterized LOC103910419

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of dietary fatty acids on mitochondrial phospholipid compositions, oxidative status and mitochondrial gene expression of zebrafish at different ages. Betancor MB, et al. Fish Physiol Biochem, 2015 Oct. PMID 26156499
  2. Cloning and sequence analysis of the beta2-microglobulin transcript from flounder, Paralichthys olivaceous. Choi W, et al. Mol Immunol, 2006 Apr. PMID 16257447
  3. Cloning of the beta 2-microglobulin gene in the zebrafish. Ono H, et al. Immunogenetics, 1993. PMID 8462988
  4. Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes. Lv X, et al. Front Cell Dev Biol, 2022. PMID 35372370, Free PMC Article
  5. Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos. Otten ABC, et al. Front Cell Dev Biol, 2020. PMID 32596237, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystallization and preliminary X-ray diffraction analysis of the two distinct types of zebrafish beta2-microglobulin has been reported.
    Title: Crystallization and preliminary X-ray diffraction analysis of the two distinct types of zebrafish β2-microglobulin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-2-microglobulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159768.1 → NP_001153240.1  beta-2-microglobulin precursor

    See identical proteins and their annotated locations for NP_001153240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC162435, CR558305
    UniProtKB/Swiss-Prot
    Q04475
    UniProtKB/TrEMBL
    B0UYS1
    Related
    ENSDARP00000110049.2, ENSDART00000131026.3
    Conserved Domains (1) summary
    cd05770
    Location:23 → 113
    IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

  2. NM_131163.2 → NP_571238.1  beta-2-microglobulin precursor

    See identical proteins and their annotated locations for NP_571238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI544722, BC062841, CR558305
    UniProtKB/Swiss-Prot
    Q04475
    UniProtKB/TrEMBL
    B0UYS1
    Related
    ENSDARP00000069612.4, ENSDART00000075127.6
    Conserved Domains (1) summary
    cd05770
    Location:23 → 113
    IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    12793396..12795493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04475.1 GenPept UniProtKB/Swiss-Prot:Q04475

Gene LinkOut

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