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Abhd10 abhydrolase domain containing 10, depalmitoylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 303953, updated on 4-Jan-2025

Summary

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Symbol
Abhd10provided by RGD
Full Name
abhydrolase domain containing 10, depalmitoylaseprovided by RGD
Primary source
RGD:1308084
See related
EnsemblRapid:ENSRNOG00000054334 AllianceGenome:RGD:1308084
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308084
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds and palmitoyl-(protein) hydrolase activity. Predicted to be involved in acyl deglucuronidation and protein depalmitoylation. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human ABHD10 (abhydrolase domain containing 10, depalmitoylase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 59.4), Brain (RPKM 50.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abhd10 in Genome Data Viewer
Location:
11q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68543860..68556059)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55081273..55095044)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60053719..60068142)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family B, member 2 Neighboring gene uncharacterized LOC102552450 Neighboring gene small nucleolar RNA U13 Neighboring gene transgelin 3 Neighboring gene transmembrane serine protease 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. Iwamura A, et al. J Biol Chem, 2012 Mar 16. PMID 22294686, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds ISO
Inferred from Sequence Orthology
more info
  
enables mycophenolic acid acyl-glucuronide esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables palmitoyl-(protein) hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in acyl deglucuronidation IEA
Inferred from Electronic Annotation
more info
  
involved_in acyl deglucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in macromolecule depalmitoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein depalmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
palmitoyl-protein thioesterase ABHD10, mitochondrial
Names
abhydrolase domain-containing protein 10, mitochondrial
acyl-protein thioesterase ABHD10
alpha/beta hydrolase domain-containing protein 10, mitochondrial
mycophenolic acid acyl-glucuronide esterase, mitochondrial
NP_001116824.1
XP_008766954.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123352.1 → NP_001116824.1  palmitoyl-protein thioesterase ABHD10, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001116824.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161919
    UniProtKB/Swiss-Prot
    Q5I0K5
    UniProtKB/TrEMBL
    A6IQX5, B1WBW9
    Related
    ENSRNOP00000071368.2, ENSRNOT00000091756.3
    Conserved Domains (1) summary
    COG0596
    Location:56 → 282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    68543860..68556059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768732.4 → XP_008766954.2  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform X1

    Conserved Domains (1) summary
    COG0596
    Location:56 → 189
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0K5.2 GenPept UniProtKB/Swiss-Prot:Q5I0K5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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