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Igsf11 immunoglobulin superfamily, member 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303926, updated on 27-Nov-2024

Summary

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Official Symbol
Igsf11provided by RGD
Official Full Name
immunoglobulin superfamily, member 11provided by RGD
Primary source
RGD:1308758
See related
EnsemblRapid:ENSRNOG00000001525 AllianceGenome:RGD:1308758
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ionotropic glutamate receptor binding activity. Involved in maintenance of protein location; positive regulation of mini excitatory postsynaptic potential; and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in excitatory synapse and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human IGSF11 (immunoglobulin superfamily member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 178.8), Kidney (RPKM 164.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Igsf11 in Genome Data Viewer
Location:
11q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75238706..75389748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (61733139..61884059, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64286691..64421248, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352339 Neighboring gene uncharacterized LOC134481003 Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin 6, pseudogene 3 Neighboring gene ribosomal protein L27 like 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. Harada H, et al. J Cell Physiol, 2005 Sep. PMID 15795899
  2. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Watanabe T, et al. Cancer Sci, 2005 Aug. PMID 16108831, Free PMC Article
  3. Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Jang S, et al. Nat Neurosci, 2016 Jan. PMID 26595655, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94879

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of protein location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mini excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in trans-synaptic signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in excitatory synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
immunoglobulin superfamily member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013120.1 → NP_001013138.1  immunoglobulin superfamily member 11 precursor

    See identical proteins and their annotated locations for NP_001013138.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085929
    UniProtKB/Swiss-Prot
    Q5U2P2
    Related
    ENSRNOP00000059779.1, ENSRNOT00000066997.4
    Conserved Domains (3) summary
    smart00410
    Location:29 → 124
    IG_like; Immunoglobulin like
    pfam07686
    Location:27 → 141
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:156 → 223
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    75238706..75389748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270528.1 → XP_063126598.1  immunoglobulin superfamily member 11 isoform X1

    Related
    ENSRNOP00000105601.1, ENSRNOT00000124458.1

  2. XM_039088359.2 → XP_038944287.1  immunoglobulin superfamily member 11 isoform X1

    Conserved Domains (3) summary
    pfam13927
    Location:99 → 160
    Ig_3; Immunoglobulin domain
    cd00096
    Location:13 → 18
    Ig; Ig strand C' [structural motif]
    cl11960
    Location:5 → 67
    Ig; Immunoglobulin domain

  3. XM_039088360.2 → XP_038944288.1  immunoglobulin superfamily member 11 isoform X1

    Conserved Domains (3) summary
    pfam13927
    Location:99 → 160
    Ig_3; Immunoglobulin domain
    cd00096
    Location:13 → 18
    Ig; Ig strand C' [structural motif]
    cl11960
    Location:5 → 67
    Ig; Immunoglobulin domain

  4. XM_063270530.1 → XP_063126600.1  immunoglobulin superfamily member 11 isoform X3

  5. XM_063270529.1 → XP_063126599.1  immunoglobulin superfamily member 11 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2P2.1 GenPept UniProtKB/Swiss-Prot:Q5U2P2

Gene LinkOut

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