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Slc49a4 solute carrier family 49 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303902, updated on 4-Jan-2025

Summary

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Official Symbol
Slc49a4provided by RGD
Official Full Name
solute carrier family 49 member 4provided by RGD
Primary source
RGD:1310939
See related
EnsemblRapid:ENSRNOG00000002240 AllianceGenome:RGD:1310939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dirc2
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in pyridoxine transport. Predicted to be located in lysosomal membrane. Predicted to be active in intracellular membrane-bounded organelle and membrane. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human SLC49A4 (solute carrier family 49 member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 159.7), Heart (RPKM 142.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc49a4 in Genome Data Viewer
Location:
11q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78500918..78574205)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64995629..65068929)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68198709..68272766)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 14 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene HSPB1 associated protein 1 Neighboring gene uncharacterized LOC108352343 Neighboring gene metastasis associated 1 family, member 2, pseudogene 1 Neighboring gene semaphorin 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21). Bodmer D, et al. Hum Mol Genet, 2002 Mar 15. PMID 11912179
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in pyridoxine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in pyridoxine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 49 member 4
Names
disrupted in renal carcinoma 2 homolog
disrupted in renal carcinoma protein 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012017.1 → NP_001012017.1  solute carrier family 49 member 4

    See identical proteins and their annotated locations for NP_001012017.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081960
    UniProtKB/Swiss-Prot
    Q66H95
    Related
    ENSRNOP00000003048.4, ENSRNOT00000003048.7
    Conserved Domains (1) summary
    cd06174
    Location:66 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    78500918..78574205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088342.2 → XP_038944270.1  solute carrier family 49 member 4 isoform X1

    UniProtKB/TrEMBL
    A6IRF5
    Conserved Domains (1) summary
    cl28910
    Location:29 → 333
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H95.1 GenPept UniProtKB/Swiss-Prot:Q66H95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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