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Nrros negative regulator of reactive oxygen species [ Rattus norvegicus (Norway rat) ]

Gene ID: 303875, updated on 9-Dec-2024

Summary

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Official Symbol
Nrrosprovided by RGD
Official Full Name
negative regulator of reactive oxygen speciesprovided by RGD
Primary source
RGD:1310771
See related
EnsemblRapid:ENSRNOG00000001752 AllianceGenome:RGD:1310771
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Garpl1; Lrrc33; RGD1310771
Summary
Predicted to enable receptor ligand inhibitor activity and transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cell surface and endoplasmic reticulum. Orthologous to human NRROS (negative regulator of reactive oxygen species). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 284.4), Spleen (RPKM 276.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nrros in Genome Data Viewer
Location:
11q22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82133608..82151160)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68628641..68646152)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71872728..71889897)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481089 Neighboring gene uncharacterized LOC120095670 Neighboring gene uncharacterized LOC134481090 Neighboring gene centrosomal protein 19 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene small nucleolar RNA SNORA17 Neighboring gene p21 (RAC1) activated kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mice deficient in NRROS show abnormal microglial development and neurological disorders. Wong K, et al. Nat Immunol, 2017 Jun. PMID 28459434
  2. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Qin Y, et al. Cell, 2018 Jun 28. PMID 29909984, Free PMC Article
  3. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Noubade R, et al. Nature, 2014 May 8. PMID 24739962
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108848

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables receptor ligand inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microglia development IEA
Inferred from Electronic Annotation
more info
  
involved_in microglia development ISO
Inferred from Sequence Orthology
more info
  
involved_in microglia development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sequestering of TGFbeta in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in sequestering of TGFbeta in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
involved_in sequestering of TGFbeta in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming growth factor beta activator LRRC33
Names
leucine rich repeat containing 33
leucine-rich repeat-containing protein 33
leucine-rich repeat-containing protein 33^

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024995.1 → NP_001020166.1  transforming growth factor beta activator LRRC33 precursor

    See identical proteins and their annotated locations for NP_001020166.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091190
    UniProtKB/Swiss-Prot
    Q5BK65
    UniProtKB/TrEMBL
    A0A8I5Y5F1, A6IRT2
    Conserved Domains (4) summary
    cd00116
    Location:328 → 549
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:537 → 574
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    82133608..82151160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248448.5 → XP_006248510.1  transforming growth factor beta activator LRRC33 isoform X1

    See identical proteins and their annotated locations for XP_006248510.1

    UniProtKB/Swiss-Prot
    Q5BK65
    UniProtKB/TrEMBL
    A0A8I5Y5F1, A6IRT2
    Related
    ENSRNOP00000109205.1, ENSRNOT00000138184.1
    Conserved Domains (4) summary
    cd00116
    Location:328 → 549
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:330 → 353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:537 → 574
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:157 → 217
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK65.1 GenPept UniProtKB/Swiss-Prot:Q5BK65

Gene LinkOut

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