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Zdhhc8 zinc finger DHHC-type palmitoyltransferase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303796, updated on 4-Jan-2025

Summary

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Official Symbol
Zdhhc8provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 8provided by RGD
Primary source
RGD:1308875
See related
EnsemblRapid:ENSRNOG00000021891 AllianceGenome:RGD:1308875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; positive regulation of cholesterol efflux; and regulation of postsynapse assembly. Predicted to act upstream of or within locomotory behavior. Predicted to be located in mitochondrion. Predicted to be active in Golgi apparatus; glutamatergic synapse; and postsynapse. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 30.3), Heart (RPKM 23.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc8 in Genome Data Viewer
Location:
11q23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96259383..96273588)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82755110..82769280)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86903122..86917261)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene coiled-coil domain containing 188 Neighboring gene uncharacterized LOC102555338

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Mukai J, et al. Nat Genet, 2004 Jul. PMID 15184899
  2. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM, et al. Neuron, 2012 Feb 9. PMID 22325201, Free PMC Article
  3. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
  5. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Ivatt RM, et al. Proc Natl Acad Sci U S A, 2014 Jun 10. PMID 24912190, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC8
Names
probable palmitoyltransferase ZDHHC8
zinc finger, DHHC domain containing 8
zinc finger, DHHC-type containing 8
zinc finger, DHHC-type containing 8-like
NP_001034110.1
XP_006248672.1
XP_038944196.1
XP_038944197.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039021.3 → NP_001034110.1  palmitoyltransferase ZDHHC8

    See identical proteins and their annotated locations for NP_001034110.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6A4S3, Q2THW6
    Related
    ENSRNOP00000040329.2, ENSRNOT00000048063.5
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96259383..96273588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088268.2 → XP_038944196.1  palmitoyltransferase ZDHHC8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4S3

  2. XM_006248610.5 → XP_006248672.1  palmitoyltransferase ZDHHC8 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4S3
    Related
    ENSRNOP00000101586.1, ENSRNOT00000132141.1
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

  3. XM_039088269.2 → XP_038944197.1  palmitoyltransferase ZDHHC8 isoform X3

    UniProtKB/TrEMBL
    A6JSI2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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