Caskin2 cask-interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Caskin2provided by RGD
Official Full Name: cask-interacting protein 2provided by RGD
Primary source: RGD:1309738
See related: EnsemblRapid:ENSRNOG00000004310 AllianceGenome:RGD:1309738
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be located in cytoplasm. Orthologous to human CASKIN2 (CASK interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 112.2), Kidney (RPKM 108.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (101526131..101540362, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101027196..101041429, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (104344035..104358256, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: caskin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107065.1 → NP_001100535.1 caskin-2

See identical proteins and their annotated locations for NP_001100535.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HKQ8, D4A9T0

Related

ENSRNOP00000005942.4, ENSRNOT00000005942.7

Conserved Domains (11) summary

cd09497
Location:487 → 552

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:553 → 623

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:561 → 620

SAM; Sterile alpha motif

cd12063
Location:284 → 345

SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2

cd00204
Location:76 → 209

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:152 → 251

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:7 → 61

Ank_4; Ankyrin repeats (many copies)

pfam15550
Location:899 → 1067

Draxin; Draxin

pfam16632
Location:1143 → 1200

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:797 → 881

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

101526131..101540362 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247717.5 → XP_006247779.1 caskin-2 isoform X1

See identical proteins and their annotated locations for XP_006247779.1

UniProtKB/TrEMBL

A6HKQ8, D4A9T0

Conserved Domains (11) summary

cd09497
Location:487 → 552

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:553 → 623

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:561 → 620

SAM; Sterile alpha motif

cd12063
Location:284 → 345

SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2

cd00204
Location:76 → 209

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:152 → 251

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:7 → 61

Ank_4; Ankyrin repeats (many copies)

pfam15550
Location:899 → 1067

Draxin; Draxin

pfam16632
Location:1143 → 1200

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:797 → 881

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]
XM_017597344.3 → XP_017452833.1 caskin-2 isoform X2

Related

ENSRNOP00000106146.1, ENSRNOT00000160205.1