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Polg2 DNA polymerase gamma 2, accessory subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 303612, updated on 4-Jan-2025

Summary

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Official Symbol
Polg2provided by RGD
Official Full Name
DNA polymerase gamma 2, accessory subunitprovided by RGD
Primary source
RGD:1305128
See related
EnsemblRapid:ENSRNOG00000013728 AllianceGenome:RGD:1305128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA polymerase binding activity; DNA polymerase processivity factor activity; and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication and positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within in utero embryonic development and mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 87.8), Kidney (RPKM 86.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Polg2 in Genome Data Viewer
Location:
10q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92212303..92222849, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91712586..91723008, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94968836..94979259, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene platelet and endothelial cell adhesion molecule 1 Neighboring gene mast cell immunoglobulin-like receptor 1 Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5 Neighboring gene centrosomal protein 95

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer. Carrodeguas JA, et al. Mol Cell, 2001 Jan. PMID 11172710
  2. Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. Carrodeguas JA, et al. Nucleic Acids Res, 2000 Mar 1. PMID 10666468, Free PMC Article
  3. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Tewari S, et al. Antioxid Redox Signal, 2012 Aug 1. PMID 22229649, Free PMC Article
  4. Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Lee YS, et al. Cell, 2009 Oct 16. PMID 19837034, Free PMC Article
  5. The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance. Lim SE, et al. J Biol Chem, 1999 Dec 31. PMID 10608893

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA polymerase processivity factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrial DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase subunit gamma-2, mitochondrial
Names
polymerase (DNA directed), gamma 2, accessory subunit
polymerase (DNA) gamma 2, accessory subunit
NP_001100530.1
XP_063125281.1
XP_063125282.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107060.1 → NP_001100530.1  DNA polymerase subunit gamma-2, mitochondrial

    See identical proteins and their annotated locations for NP_001100530.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HK56, D3ZYP7
    Related
    ENSRNOP00000018394.3, ENSRNOT00000018394.6
    Conserved Domains (2) summary
    cd02426
    Location:328 → 455
    Pol_gamma_b_Cterm; C-terminal domain of mitochondrial DNA polymerase gamma B subunit, which is required for processivity. Polymerase gamma replicates and repairs mitochondrial DNA. The c-terminal domain of its B subunit is strikingly similar to the anticodon-binding domain ...
    cl00268
    Location:43 → 324
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    92212303..92222849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269211.1 → XP_063125281.1  DNA polymerase subunit gamma-2, mitochondrial isoform X1

  2. XM_063269212.1 → XP_063125282.1  DNA polymerase subunit gamma-2, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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