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Strada STE20 related adaptor alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 303605, updated on 4-Jan-2025

Summary

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Official Symbol
Stradaprovided by RGD
Official Full Name
STE20 related adaptor alphaprovided by RGD
Primary source
RGD:727905
See related
EnsemblRapid:ENSRNOG00000008637 AllianceGenome:RGD:727905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lyk5
Summary
Contributes to protein serine/threonine kinase activity. Involved in activation of protein kinase activity. Part of protein-containing complex. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 169.9), Adrenal (RPKM 95.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Strada in Genome Data Viewer
Location:
10q32.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91594648..91623710, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91094849..91123890, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94355369..94384404, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitogen activated protein kinase kinase kinase 3 Neighboring gene LIM domain containing 2 Neighboring gene coiled-coil domain containing 47 Neighboring gene DEAD-box helicase 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LKB1/STRAD promotes axon initiation during neuronal polarization. Shelly M, et al. Cell, 2007 May 4. PMID 17482549
  2. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. Baas AF, et al. EMBO J, 2003 Jun 16. PMID 12805220, Free PMC Article
  3. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Zeqiraj E, et al. Science, 2009 Dec 18. PMID 19892943, Free PMC Article
  4. Characterization of an alternative splice variant of LKB1. Denison FC, et al. J Biol Chem, 2009 Jan 2. PMID 18854309
  5. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. Lan F, et al. J Biol Chem, 2008 Oct 10. PMID 18687677, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation [STRAD protein]
    Title: LKB1/STRAD promotes axon initiation during neuronal polarization.
  2. LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK.
    Title: SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93856

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_negative_effect G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of intracellular protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of intracellular protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of serine/threonine protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine/threonine protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of serine/threonine protein kinase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
STE20-related kinase adapter protein alpha
Names
STE20-related adapter protein
STE20-related kinase adaptor alpha
STRAD alpha
protein kinase LYK5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415111.1 → NP_001402040.1  STE20-related kinase adapter protein alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HK11, F1M341

  2. NM_001415112.1 → NP_001402041.1  STE20-related kinase adapter protein alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZXZ5, A6HK12, F1M341

  3. NM_001415113.1 → NP_001402042.1  STE20-related kinase adapter protein alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZXZ5, A6HK12, F1M341

  4. NM_182820.3 → NP_877972.2  STE20-related kinase adapter protein alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q66HD4, Q7TNZ6
    UniProtKB/TrEMBL
    A6HK10
    Related
    ENSRNOP00000081722.1, ENSRNOT00000119526.2
    Conserved Domains (1) summary
    cd08227
    Location:33 → 359
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91594648..91623710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269203.1 → XP_063125273.1  STE20-related kinase adapter protein alpha isoform X7

    UniProtKB/TrEMBL
    F1M341

  2. XM_063269204.1 → XP_063125274.1  STE20-related kinase adapter protein alpha isoform X9

    UniProtKB/Swiss-Prot
    Q66HD4, Q7TNZ6

  3. XM_008768362.3 → XP_008766584.1  STE20-related kinase adapter protein alpha isoform X8

    UniProtKB/Swiss-Prot
    Q66HD4, Q7TNZ6
    Conserved Domains (2) summary
    smart00220
    Location:32 → 342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:33 → 365
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039086166.2 → XP_038942094.1  STE20-related kinase adapter protein alpha isoform X5

    UniProtKB/TrEMBL
    A0A8I6GKR2, F1M341
    Conserved Domains (1) summary
    cd08227
    Location:62 → 388
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

  5. XM_063269202.1 → XP_063125272.1  STE20-related kinase adapter protein alpha isoform X4

    UniProtKB/TrEMBL
    F1M341

  6. XM_008768360.3 → XP_008766582.1  STE20-related kinase adapter protein alpha isoform X3

    UniProtKB/TrEMBL
    F1M341
    Conserved Domains (2) summary
    smart00220
    Location:61 → 371
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:62 → 394
    PKc_like; Protein Kinases, catalytic domain

  7. XM_063269205.1 → XP_063125275.1  STE20-related kinase adapter protein alpha isoform X10

    UniProtKB/TrEMBL
    F1M341, G3V9L2
    Related
    ENSRNOP00000051998.5, ENSRNOT00000055125.6

  8. XM_008768361.3 → XP_008766583.1  STE20-related kinase adapter protein alpha isoform X6

    UniProtKB/TrEMBL
    F1M341
    Conserved Domains (2) summary
    smart00220
    Location:40 → 350
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:41 → 373
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006247586.4 → XP_006247648.1  STE20-related kinase adapter protein alpha isoform X2

    UniProtKB/TrEMBL
    F1M341
    Related
    ENSRNOP00000094426.2, ENSRNOT00000094696.2
    Conserved Domains (2) summary
    smart00220
    Location:69 → 379
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70 → 401
    PKc_like; Protein Kinases, catalytic domain

  10. XM_008768359.3 → XP_008766581.1  STE20-related kinase adapter protein alpha isoform X1

    UniProtKB/TrEMBL
    F1M341
    Conserved Domains (2) summary
    smart00220
    Location:69 → 379
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70 → 402
    PKc_like; Protein Kinases, catalytic domain

  11. XM_039086167.2 → XP_038942095.1  STE20-related kinase adapter protein alpha isoform X11

    UniProtKB/TrEMBL
    F1M341
    Conserved Domains (1) summary
    cl21453
    Location:12 → 344
    PKc_like; Protein Kinases, catalytic domain

  12. XM_008768364.3 → XP_008766586.1  STE20-related kinase adapter protein alpha isoform X11

    See identical proteins and their annotated locations for XP_008766586.1

    UniProtKB/TrEMBL
    F1M341
    Conserved Domains (1) summary
    cl21453
    Location:12 → 344
    PKc_like; Protein Kinases, catalytic domain

  13. XM_063269206.1 → XP_063125276.1  STE20-related kinase adapter protein alpha isoform X11

    UniProtKB/TrEMBL
    F1M341

  14. XM_063269207.1 → XP_063125277.1  STE20-related kinase adapter protein alpha isoform X12

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNZ6.1 GenPept UniProtKB/Swiss-Prot:Q7TNZ6

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