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Tmub2 transmembrane and ubiquitin-like domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303567, updated on 27-Nov-2024

Summary

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Official Symbol
Tmub2provided by RGD
Official Full Name
transmembrane and ubiquitin-like domain containing 2provided by RGD
Primary source
RGD:1304758
See related
EnsemblRapid:ENSRNOG00000020916 AllianceGenome:RGD:1304758
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304758
Summary
Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Orthologous to human TMUB2 (transmembrane and ubiquitin like domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 119.1), Kidney (RPKM 109.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmub2 in Genome Data Viewer
Location:
10q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87738662..87743118)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87238543..87242968)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90230428..90234874)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene homologous recombination factor with OB-fold Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene ataxin 7-like 3 Neighboring gene uncharacterized LOC134480881 Neighboring gene upstream binding transcription factor Neighboring gene solute carrier family 4 member 1 (Diego blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116065

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and ubiquitin-like domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031651.2 → NP_001026821.1  transmembrane and ubiquitin-like domain-containing protein 2

    See identical proteins and their annotated locations for NP_001026821.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085794
    UniProtKB/Swiss-Prot
    Q0P5P8, Q4FZV7
    UniProtKB/TrEMBL
    A0A8I6A9G1, A6HJH8
    Related
    ENSRNOP00000073316.1, ENSRNOT00000082722.3
    Conserved Domains (2) summary
    smart00213
    Location:173 → 240
    UBQ; Ubiquitin homologues
    pfam00240
    Location:191 → 244
    ubiquitin; Ubiquitin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    87738662..87743118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247331.5 → XP_006247393.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9G1, A0A8L2QQ50
    Related
    ENSRNOP00000052057.3, ENSRNOT00000055185.4
    Conserved Domains (2) summary
    smart00213
    Location:209 → 276
    UBQ; Ubiquitin homologues
    pfam00240
    Location:227 → 280
    ubiquitin; Ubiquitin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZV7.1 GenPept UniProtKB/Swiss-Prot:Q4FZV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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