Nags N-acetylglutamate synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nagsprovided by RGD
Official Full Name: N-acetylglutamate synthaseprovided by RGD
Primary source: RGD:1565783
See related: EnsemblRapid:ENSRNOG00000020879 AllianceGenome:RGD:1565783
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565783
Summary: Predicted to enable L-glutamate N-acetyltransferase activity. Predicted to be involved in L-arginine biosynthetic process and glutamate metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 151.1) and Spleen (RPKM 11.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87598516..87602650)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87098330..87102465)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90084607..90089693)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-glutamate N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables L-glutamate N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in glutamate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutamate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-acetylglutamate synthase, mitochondrial

NP_001100523.1

EC 2.3.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107053.1 → NP_001100523.1 N-acetylglutamate synthase, mitochondrial

See identical proteins and their annotated locations for NP_001100523.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HJG6, D4A904

Related

ENSRNOP00000028332.5, ENSRNOT00000028332.7

Conserved Domains (2) summary

pfam04768
Location:350 → 513

NAT; N-acetyltransferase, of N-acetylglutamate synthase

cl00452
Location:95 → 364

AAK; Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that ...