Nbr1 NBR1, autophagy cargo receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nbr1provided by RGD
Official Full Name: NBR1, autophagy cargo receptorprovided by RGD
Primary source: RGD:69195
See related: EnsemblRapid:ENSRNOG00000020730 AllianceGenome:RGD:69195
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca125; RGD1311421
Summary: Predicted to enable mitogen-activated protein kinase binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast differentiation; regulation of bone mineralization; and regulation of stress-activated MAPK cascade. Predicted to be located in several cellular components, including autophagosome; late endosome; and mitochondrial intermembrane space. Predicted to be part of receptor complex. Predicted to be active in phagophore assembly site. Orthologous to human NBR1 (NBR1 autophagy cargo receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 560.9), Kidney (RPKM 554.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86978024..87006664)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86477775..86506418)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89455202..89483791)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in M band	IEA Inferred from Electronic Annotation more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: next to BRCA1 gene 1 protein

Names: neighbor of BRCA1 gene 1 protein; next to the Brca1; ovarian carcinoma antigen CA125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024765.1 → NP_001019936.1 next to BRCA1 gene 1 protein

See identical proteins and their annotated locations for NP_001019936.1

Status: PROVISIONAL

Source sequence(s)

BC095903

UniProtKB/Swiss-Prot

Q501R9, Q9JHG4

UniProtKB/TrEMBL

A0A8I5ZQ89

Related

ENSRNOP00000028149.7, ENSRNOT00000028149.9

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:933 → 971

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86978024..87006664

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597321.3 → XP_017452810.1 next to BRCA1 gene 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZQ89, A6HJD4, F1LSE5

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:933 → 971

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_063269136.1 → XP_063125206.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

A0A0G2K0K7, A0A8I6A311
XM_006247324.5 → XP_006247386.1 next to BRCA1 gene 1 protein isoform X1

See identical proteins and their annotated locations for XP_006247386.1

UniProtKB/TrEMBL

A0A8I5ZQ89, A6HJD4, F1LSE5

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:933 → 971

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_063269135.1 → XP_063125205.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

A0A0G2K0K7, A0A8I6A311
XM_063269131.1 → XP_063125201.1 next to BRCA1 gene 1 protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ89, A0A8I6G713
XM_063269140.1 → XP_063125210.1 next to BRCA1 gene 1 protein isoform X5

UniProtKB/TrEMBL

A0A8I6A311
XM_006247323.4 → XP_006247385.1 next to BRCA1 gene 1 protein isoform X1

See identical proteins and their annotated locations for XP_006247385.1

UniProtKB/TrEMBL

A0A8I5ZQ89, A6HJD4, F1LSE5

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:933 → 971

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_063269134.1 → XP_063125204.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

A0A0G2K0K7, A0A8I6A311
XM_063269130.1 → XP_063125200.1 next to BRCA1 gene 1 protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ89, A0A8I6G713
XM_063269139.1 → XP_063125209.1 next to BRCA1 gene 1 protein isoform X4

UniProtKB/TrEMBL

A0A8I6A311
XM_006247321.5 → XP_006247383.1 next to BRCA1 gene 1 protein isoform X1

See identical proteins and their annotated locations for XP_006247383.1

UniProtKB/TrEMBL

A0A8I5ZQ89, A6HJD4, F1LSE5

Related

ENSRNOP00000085324.2, ENSRNOT00000116011.2

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:933 → 971

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_063269132.1 → XP_063125202.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

A0A0G2K0K7, A0A8I6A311
XM_063269128.1 → XP_063125198.1 next to BRCA1 gene 1 protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ89, A0A8I6G713
XM_063269137.1 → XP_063125207.1 next to BRCA1 gene 1 protein isoform X4

UniProtKB/TrEMBL

A0A8I6A311
XM_006247322.5 → XP_006247384.1 next to BRCA1 gene 1 protein isoform X1

See identical proteins and their annotated locations for XP_006247384.1

UniProtKB/TrEMBL

A0A8I5ZQ89, A6HJD4, F1LSE5

Related

ENSRNOP00000104389.1, ENSRNOT00000153438.1

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:933 → 971

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_063269133.1 → XP_063125203.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

A0A0G2K0K7, A0A8I6A311

Related

ENSRNOP00000071486.2, ENSRNOT00000077942.3
XM_063269129.1 → XP_063125199.1 next to BRCA1 gene 1 protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ89, A0A8I6G713
XM_063269138.1 → XP_063125208.1 next to BRCA1 gene 1 protein isoform X4

UniProtKB/TrEMBL

A0A8I6A311
XM_006247326.5 → XP_006247388.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

A0A0G2K0K7, A0A8I6A311

Conserved Domains (3) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_039086098.2 → XP_038942026.1 next to BRCA1 gene 1 protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ89, A0A8I6G713

Related

ENSRNOP00000080729.1, ENSRNOT00000115139.2

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:217 → 261

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:896 → 934

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:371 → 481

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins