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Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303536, updated on 27-Nov-2024

Summary

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Official Symbol
Dnajc7provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C7provided by RGD
Primary source
RGD:1303226
See related
EnsemblRapid:ENSRNOG00000017781 AllianceGenome:RGD:1303226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CCRP
Summary
Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 321.6), Muscle (RPKM 292.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc7 in Genome Data Viewer
Location:
10q31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86018977..86055419, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85518637..85555079, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88498271..88533730, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene NFKB inhibitor interacting Ras-like 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene chromosome 10 C17orf113 homolog pseudogene Neighboring gene zinc finger protein 385C Neighboring gene uncharacterized LOC120095293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of the cochaperone Tpr2 in Hsp90 chaperoning. Moffatt NS, et al. Biochemistry, 2008 Aug 5. PMID 18620420
  2. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. Brychzy A, et al. EMBO J, 2003 Jul 15. PMID 12853476, Free PMC Article
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105609

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 7
Names
DnaJ (Hsp40) homolog, subfamily C, member 7
cytoplasmic CAR retention protein
cytoplasmic constitutive active/androstane receptor retention protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213625.2 → NP_998790.2  dnaJ homolog subfamily C member 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HJ46
    Related
    ENSRNOP00000103216.1, ENSRNOT00000134339.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86018977..86055419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247311.5 → XP_006247373.1  dnaJ homolog subfamily C member 7 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K435, Q75N36
    Related
    ENSRNOP00000072889.1, ENSRNOT00000080521.3
    Conserved Domains (8) summary
    smart00028
    Location:113 → 146
    TPR; Tetratricopeptide repeats
    COG0484
    Location:465 → 554
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:342 → 369
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:466 → 533
    DnaJ; DnaJ domain
    pfam00515
    Location:379 → 412
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:112 → 177
    TPR_11; TPR repeat
    pfam13431
    Location:135 → 167
    TPR_17; Tetratricopeptide repeat
    cl00292
    Location:19 → 91
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

  2. XM_006247313.4 → XP_006247375.1  dnaJ homolog subfamily C member 7 isoform X4

    See identical proteins and their annotated locations for XP_006247375.1

    UniProtKB/TrEMBL
    A0A8J8XPI1, Q75N36
    Conserved Domains (4) summary
    PLN03088
    Location:197 → 297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0484
    Location:324 → 413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    TIGR02917
    Location:3 → 328
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:201 → 228
    TPR; TPR repeat [structural motif]

  3. XM_006247312.5 → XP_006247374.1  dnaJ homolog subfamily C member 7 isoform X2

    UniProtKB/TrEMBL
    G3V8B8, Q566E2, Q75N36
    Related
    ENSRNOP00000024321.6, ENSRNOT00000024321.8
    Conserved Domains (7) summary
    smart00028
    Location:12 → 45
    TPR; Tetratricopeptide repeats
    COG0484
    Location:364 → 453
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:241 → 268
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:365 → 432
    DnaJ; DnaJ domain
    pfam00515
    Location:278 → 311
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:11 → 76
    TPR_11; TPR repeat
    pfam13431
    Location:34 → 66
    TPR_17; Tetratricopeptide repeat

  4. XM_039086092.2 → XP_038942020.1  dnaJ homolog subfamily C member 7 isoform X4

    UniProtKB/TrEMBL
    A0A8J8XPI1, Q75N36
    Conserved Domains (4) summary
    PLN03088
    Location:197 → 297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0484
    Location:324 → 413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    TIGR02917
    Location:3 → 328
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:201 → 228
    TPR; TPR repeat [structural motif]

  5. XM_063269125.1 → XP_063125195.1  dnaJ homolog subfamily C member 7 isoform X3

RNA

  1. XR_594788.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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