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Psmd11 proteasome 26S subunit, non-ATPase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303353, updated on 27-Nov-2024

Summary

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Official Symbol
Psmd11provided by RGD
Official Full Name
proteasome 26S subunit, non-ATPase 11provided by RGD
Primary source
RGD:1306450
See related
EnsemblRapid:ENSRNOG00000005538 AllianceGenome:RGD:1306450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable structural molecule activity. Predicted to be involved in proteasome assembly; stem cell differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 190.0), Liver (RPKM 173.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Psmd11 in Genome Data Viewer
Location:
10q26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65923669..65977523)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65433853..65479774)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67810655..67857562)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 17 open reading frame 75 Neighboring gene microRNA 632 Neighboring gene zinc finger protein 207 Neighboring gene cyclin-dependent kinase 5 regulatory subunit 1 like Neighboring gene cyclin-dependent kinase 5 regulatory subunit 1 Neighboring gene myosin ID Neighboring gene uncharacterized LOC134480833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Vilchez D, et al. Nature, 2012 Sep 13. PMID 22972301, Free PMC Article
  2. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
  3. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
  4. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966
  5. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Wang X, et al. Biochemistry, 2007 Mar 20. PMID 17323924

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome accessory complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 11
Names
26S proteasome regulatory subunit RPN6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394006.1 → NP_001380935.1  26S proteasome non-ATPase regulatory subunit 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    F1LMZ8
    UniProtKB/TrEMBL
    B5DEP6
    Related
    ENSRNOP00000062146.2, ENSRNOT00000064285.4
    Conserved Domains (1) summary
    COG5159
    Location:17 → 421
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

RNA

  1. NR_172065.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65923669..65977523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269077.1 → XP_063125147.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWX1, A6HHB7

  2. XM_006246988.4 → XP_006247050.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

    See identical proteins and their annotated locations for XP_006247050.1

    UniProtKB/TrEMBL
    A0A0G2JWX1, A0A8I5ZWU3, A6HHB7
    Conserved Domains (2) summary
    COG5159
    Location:95 → 499
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:363 → 467
    PCI; PCI domain

  3. XM_006246987.4 → XP_006247049.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

    See identical proteins and their annotated locations for XP_006247049.1

    UniProtKB/TrEMBL
    A0A0G2JWX1, A0A8I5ZWU3, A6HHB7
    Related
    ENSRNOP00000070048.1, ENSRNOT00000079156.3
    Conserved Domains (2) summary
    COG5159
    Location:95 → 499
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:363 → 467
    PCI; PCI domain

  4. XM_063269078.1 → XP_063125148.1  26S proteasome non-ATPase regulatory subunit 11 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LMZ8.2 GenPept UniProtKB/Swiss-Prot:F1LMZ8

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