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Rhot1 ras homolog family member T1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303351, updated on 4-Jan-2025

Summary

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Official Symbol
Rhot1provided by RGD
Official Full Name
ras homolog family member T1provided by RGD
Primary source
RGD:1307023
See related
EnsemblRapid:ENSRNOG00000004093 AllianceGenome:RGD:1307023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Involved in establishment of mitochondrion localization by microtubule attachment; regulation of neurotransmitter secretion; and regulation of organelle transport along microtubule. Predicted to be located in mitochondrial outer membrane. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 280.7), Adrenal (RPKM 216.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhot1 in Genome Data Viewer
Location:
10q25-q26
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65685687..65760682)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65198700..65262807)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67559277..67640622)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480832 Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene ring finger protein 135 Neighboring gene rhomboid like 3 Neighboring gene similar to human chromosome 17 open reading frame 75

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis. Man G, et al. J Immunol Res, 2022. PMID 35300071, Free PMC Article
  2. Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission. Su B, et al. J Biol Chem, 2014 Jan 17. PMID 24302729, Free PMC Article
  3. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. Kalinski AL, et al. J Cell Biol, 2019 Jun 3. PMID 31068376, Free PMC Article
  4. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. MacAskill AF, et al. Mol Cell Neurosci, 2009 Mar. PMID 19103291
  5. Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Saotome M, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19098100, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.
    Title: Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.
  2. The data point to HDAC6-dependent deacetylation of Miro1 as a mediator of axon growth inhibition through decreased mitochondrial transport.
    Title: Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.
  3. These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons.
    Title: GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.
  4. Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
    Title: Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC156790

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitochondrion localization by microtubule attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial outer membrane permeabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of organelle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial Rho GTPase 1
Names
ras homolog gene family, member T1
NP_001100496.1
XP_017452795.1
XP_038941952.1
XP_038941953.1
XP_063125144.1
XP_063125145.1
XP_063125146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107026.2 → NP_001100496.1  mitochondrial Rho GTPase 1

    See identical proteins and their annotated locations for NP_001100496.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129123
    UniProtKB/TrEMBL
    A1L1L6, F7EK49
    Related
    ENSRNOP00000107396.1, ENSRNOT00000137581.1
    Conserved Domains (4) summary
    cd01892
    Location:428 → 605
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 423
    EF_assoc_1; EF hand associated
    pfam08356
    Location:232 → 316
    EF_assoc_2; EF hand associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65685687..65760682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269076.1 → XP_063125146.1  mitochondrial Rho GTPase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AMM4

  2. XM_063269074.1 → XP_063125144.1  mitochondrial Rho GTPase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K777, F7EK49
    Related
    ENSRNOP00000074094.1, ENSRNOT00000082685.3

  3. XM_017597306.3 → XP_017452795.1  mitochondrial Rho GTPase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AVD9, F7EK49
    Related
    ENSRNOP00000097730.1, ENSRNOT00000112911.2
    Conserved Domains (4) summary
    cd01892
    Location:428 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 423
    EF_assoc_1; EF hand associated
    pfam08356
    Location:232 → 316
    EF_assoc_2; EF hand associated

  4. XM_039086025.2 → XP_038941953.1  mitochondrial Rho GTPase 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K8T2, F7EK49
    Related
    ENSRNOP00000074726.2, ENSRNOT00000079696.3
    Conserved Domains (4) summary
    cd01892
    Location:428 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 423
    EF_assoc_1; EF hand associated
    pfam08356
    Location:232 → 316
    EF_assoc_2; EF hand associated

  5. XM_063269075.1 → XP_063125145.1  mitochondrial Rho GTPase 1 isoform X2

    UniProtKB/TrEMBL
    F7EK49
    Related
    ENSRNOP00000092578.2, ENSRNOT00000108985.2

  6. XM_039086024.2 → XP_038941952.1  mitochondrial Rho GTPase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGU0, A6HHA9, F7EK49
    Conserved Domains (4) summary
    cd01892
    Location:428 → 594
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 423
    EF_assoc_1; EF hand associated
    pfam08356
    Location:232 → 316
    EF_assoc_2; EF hand associated
Nucleotide Protein Strain
Heading Accession and Version

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