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Mink1 misshapen-like kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303259, updated on 27-Nov-2024

Summary

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Official Symbol
Mink1provided by RGD
Official Full Name
misshapen-like kinase 1provided by RGD
Primary source
RGD:1359135
See related
EnsemblRapid:ENSRNOG00000033508 AllianceGenome:RGD:1359135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MEKKK 6
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including dendrite morphogenesis; neuron cellular homeostasis; and regulation of AMPA receptor activity. Is active in glutamatergic synapse and postsynapse. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 281.3), Kidney (RPKM 229.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mink1 in Genome Data Viewer
Location:
10q24
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55776879..55829406)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55278293..55330782)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57185310..57238531)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 4 Neighboring gene phospholipase D2 Neighboring gene uncharacterized LOC134480817 Neighboring gene similar to human chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene ribosomal protein L36A, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. Dan I, et al. FEBS Lett, 2000 Mar 3. PMID 10708748
  2. MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. Hussain NK, et al. J Neurosci, 2010 Nov 3. PMID 21048137, Free PMC Article
  3. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. Hu Y, et al. J Biol Chem, 2004 Dec 24. PMID 15469942
  4. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Nonaka H, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930710
  5. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. McCarty N, et al. Nat Immunol, 2005 Jan. PMID 15608642

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative thymic T cell selection ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
misshapen-like kinase 1
Names
GCK family kinase MiNK
MAPK/ERK kinase kinase kinase 6
MEK kinase kinase 6
misshapen/NIK-related kinase
mitogen-activated protein kinase kinase kinase kinase 6
NP_001258065.1
NP_001401281.1
NP_001401282.1
XP_006246778.1
XP_006246779.1
XP_006246782.1
XP_006246783.1
XP_006246785.1
XP_006246786.1
XP_063125105.1
XP_063125106.1
XP_063125107.1
XP_063125108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271136.2 → NP_001258065.1  misshapen-like kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    F1LP90
    Conserved Domains (3) summary
    smart00036
    Location:1036 → 1334
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  2. NM_001414352.1 → NP_001401281.1  misshapen-like kinase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000069380.3, ENSRNOT00000086374.3

  3. NM_001414353.1 → NP_001401282.1  misshapen-like kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000078263.1, ENSRNOT00000109649.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55776879..55829406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269038.1 → XP_063125108.1  misshapen-like kinase 1 isoform X10

  2. XM_006246717.5 → XP_006246779.1  misshapen-like kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    F1LP90
    Conserved Domains (3) summary
    smart00036
    Location:1065 → 1363
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  3. XM_063269035.1 → XP_063125105.1  misshapen-like kinase 1 isoform X3

  4. XM_006246716.5 → XP_006246778.1  misshapen-like kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    F1LP90
    Conserved Domains (3) summary
    smart00036
    Location:1066 → 1364
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  5. XM_006246721.5 → XP_006246783.1  misshapen-like kinase 1 isoform X5

    UniProtKB/Swiss-Prot
    F1LP90
    UniProtKB/TrEMBL
    A0A8I6B5X1
    Related
    ENSRNOP00000097542.1, ENSRNOT00000102912.2
    Conserved Domains (3) summary
    smart00036
    Location:1029 → 1327
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  6. XM_063269037.1 → XP_063125107.1  misshapen-like kinase 1 isoform X7

  7. XM_063269036.1 → XP_063125106.1  misshapen-like kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JV77

  8. XM_006246720.5 → XP_006246782.1  misshapen-like kinase 1 isoform X4

    See identical proteins and their annotated locations for XP_006246782.1

    UniProtKB/Swiss-Prot
    F1LP90
    UniProtKB/TrEMBL
    A6HG65, F1LN69
    Related
    ENSRNOP00000050929.6, ENSRNOT00000040488.7
    Conserved Domains (3) summary
    smart00036
    Location:1037 → 1335
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  9. XM_006246723.5 → XP_006246785.1  misshapen-like kinase 1 isoform X8

    See identical proteins and their annotated locations for XP_006246785.1

    UniProtKB/Swiss-Prot
    F1LP90
    UniProtKB/TrEMBL
    A6HG66
    Conserved Domains (3) summary
    smart00036
    Location:1000 → 1298
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  10. XM_006246724.5 → XP_006246786.1  misshapen-like kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006246786.1

    UniProtKB/Swiss-Prot
    F1LP90
    UniProtKB/TrEMBL
    A6HG67
    Conserved Domains (3) summary
    smart00036
    Location:992 → 1290
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RNA

  1. XR_005489826.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LP90.2 GenPept UniProtKB/Swiss-Prot:F1LP90

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