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Mgat4b alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [ Rattus norvegicus (Norway rat) ]

Gene ID: 303100, updated on 27-Nov-2024

Summary

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Official Symbol
Mgat4bprovided by RGD
Official Full Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Bprovided by RGD
Primary source
RGD:1562836
See related
EnsemblRapid:ENSRNOG00000003235 AllianceGenome:RGD:1562836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562836
Summary
Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 114.3), Liver (RPKM 83.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mgat4b in Genome Data Viewer
Location:
10q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35049421..35060307)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34548918..34559229)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35726501..35736338)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095090 Neighboring gene MRN complex interacting protein Neighboring gene sequestosome 1 Neighboring gene uncharacterized LOC134480781 Neighboring gene leukotriene C4 synthase Neighboring gene mastermind-like transcriptional coactivator 1 Neighboring gene uncharacterized LOC120095092 Neighboring gene calnexin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Takamatsu S, et al. Glycobiology, 2010 Jan. PMID 20015870, Free PMC Article
  2. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Names
mannoside acetylglucosaminyltransferase 4, isoenzyme B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
NP_001121005.1
XP_006246312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127533.1 → NP_001121005.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B precursor

    See identical proteins and their annotated locations for NP_001121005.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6AKR6, B2GV39, F7FHE8
    Related
    ENSRNOP00000093801.1, ENSRNOT00000103336.2
    Conserved Domains (2) summary
    pfam04666
    Location:110 → 387
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:294 → 314
    PGAP4-like; putative TM2 helix [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    35049421..35060307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246250.4 → XP_006246312.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform X1

    UniProtKB/TrEMBL
    A0A8I6AKR6
    Related
    ENSRNOP00000004323.6, ENSRNOT00000004323.7
    Conserved Domains (1) summary
    pfam04666
    Location:110 → 387
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
Nucleotide Protein Strain
Heading Accession and Version

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