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ndrg3a ndrg family member 3a [ Danio rerio (zebrafish) ]

Gene ID: 30286, updated on 9-Dec-2024

Summary

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Official Symbol
ndrg3aprovided by ZNC
Official Full Name
ndrg family member 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-124
See related
Ensembl:ENSDARG00000013087 AllianceGenome:ZFIN:ZDB-GENE-980526-124
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ndr3; ndrg3; fc04h03; zgc:63551; wu:fc04h03
Summary
Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including corpuscles of Stannius; pectoral fin bud; pharyngeal pouch; pronephric duct; and thymus. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ndrg3a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25064536..25139061)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24826884..24901445)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 46a Neighboring gene PHD finger protein 20, a Neighboring gene Src like adaptor 2a Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein a Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes. Zinani OQH, et al. iScience, 2022 Jul 15. PMID 35789861, Free PMC Article
  2. Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. Le N, et al. FASEB J, 2021 Nov. PMID 34665878, Free PMC Article
  3. Effects of NDRG1 family proteins on photoreceptor outer segment morphology in zebrafish. Takita S, et al. Sci Rep, 2016 Nov 4. PMID 27811999, Free PMC Article
  4. Periodic inhibition of Erk activity drives sequential somite segmentation. Simsek MF, et al. Nature, 2023 Jan. PMID 36517597, Free PMC Article
  5. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. Park JS, et al. Elife, 2022 Oct 10. PMID 36214665, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
protein NDRG3a
Names
N-myc downstream regulated 3
N-myc downstream regulated family member 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199517.1 → NP_955811.1  protein NDRG3a

    See identical proteins and their annotated locations for NP_955811.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055138
    UniProtKB/TrEMBL
    A0A8M1PDZ6, Q7SY38
    Related
    ENSDARP00000005974.9, ENSDART00000016181.11
    Conserved Domains (2) summary
    COG0596
    Location:41 → 311
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:31 → 316
    Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    25064536..25139061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479547.2 → XP_021335222.1  protein NDRG3a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PUP4
    Conserved Domains (1) summary
    pfam03096
    Location:31 → 316
    Ndr; Ndr family

  2. XM_009306019.4 → XP_009304294.1  protein NDRG3a isoform X1

    See identical proteins and their annotated locations for XP_009304294.1

    UniProtKB/TrEMBL
    A0A8M9PUP4
    Conserved Domains (1) summary
    pfam03096
    Location:31 → 316
    Ndr; Ndr family

  3. XM_005169249.4 → XP_005169306.1  protein NDRG3a isoform X1

    See identical proteins and their annotated locations for XP_005169306.1

    UniProtKB/TrEMBL
    A0A8M9PUP4
    Related
    ENSDARP00000151480.1, ENSDART00000183700.1
    Conserved Domains (1) summary
    pfam03096
    Location:31 → 316
    Ndr; Ndr family

  4. XM_068224102.1 → XP_068080203.1  protein NDRG3a isoform X3

    UniProtKB/TrEMBL
    A0A8M1PDZ6, Q7SY38

  5. XM_005169250.5 → XP_005169307.1  protein NDRG3a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGH5, E7FEZ7
    Related
    ENSDARP00000105614.2, ENSDART00000128705.3
    Conserved Domains (2) summary
    COG0596
    Location:28 → 298
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:18 → 303
    Ndr; Ndr family
Nucleotide Protein Strain
Heading Accession and Version

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