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Tbc1d25 TBC1 domain family, member 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302552, updated on 27-Nov-2024

Summary

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Official Symbol
Tbc1d25provided by RGD
Official Full Name
TBC1 domain family, member 25provided by RGD
Primary source
RGD:1559711
See related
EnsemblRapid:ENSRNOG00000005303 AllianceGenome:RGD:1559711
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oatl1; RGD1559711
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of autophagosome maturation. Predicted to be active in autophagosome. Orthologous to human TBC1D25 (TBC1 domain family member 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 33.5), Kidney (RPKM 33.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbc1d25 in Genome Data Viewer
Location:
Xq12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (16986629..17010228)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14314095..14339171)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15064733..15088579)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene porcupine O-acyltransferase Neighboring gene EBP, cholestenol delta-isomerase Neighboring gene RNA binding motif protein 3 Neighboring gene WD repeat domain 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade. Liu Z, et al. In Vitro Cell Dev Biol Anim, 2023 Dec. PMID 38100060
  2. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. Itoh T, et al. J Cell Biol, 2011 Mar 7. PMID 21383079, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
    Title: TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC1 domain family member 25
Names
ornithine aminotransferase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106955.2 → NP_001100425.1  TBC1 domain family member 25

    See identical proteins and their annotated locations for NP_001100425.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161862
    UniProtKB/TrEMBL
    B1WBS1, F7F8Z1
    Related
    ENSRNOP00000095370.2, ENSRNOT00000099656.2
    Conserved Domains (1) summary
    smart00164
    Location:225 → 454
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    16986629..17010228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601993.3 → XP_017457482.1  TBC1 domain family member 25 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALA8

  2. XM_063279918.1 → XP_063135988.1  TBC1 domain family member 25 isoform X3

  3. XM_063279917.1 → XP_063135987.1  TBC1 domain family member 25 isoform X3

  4. XM_006256701.5 → XP_006256763.1  TBC1 domain family member 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALA8
    Conserved Domains (1) summary
    smart00164
    Location:193 → 422
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein Strain
Heading Accession and Version

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