Atp6ap2 ATPase H+ transporting accessory protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6ap2provided by RGD
Official Full Name: ATPase H+ transporting accessory protein 2provided by RGD
Primary source: RGD:1561269
See related: EnsemblRapid:ENSRNOG00000003858 AllianceGenome:RGD:1561269
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including angiotensin maturation; nervous system development; and regulation of signal transduction. Located in apical plasma membrane; cell body; and extracellular space. Is active in synaptic vesicle membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 815.9), Kidney (RPKM 731.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (12856708..12883670, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (10183983..10210948, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (11137889..11164854, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP6AP2 is robustly expressed in pancreatic beta cells and neuroendocrine tumors, and plays a role in maintaining cellular viability.
Title: ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viability.
Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease.
Title: Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease.
The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule.
Title: The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule.
(Pro)renin receptor involves in myocardial fibrosis and oxidative stress in diabetic cardiomyopathy via the PRR-YAP pathway.
Title: (Pro)renin receptor involves in myocardial fibrosis and oxidative stress in diabetic cardiomyopathy via the PRR-YAP pathway.
Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis.
Title: Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis.
(Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
Title: (Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
(Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis.
Title: (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/β-catenin pathways in glomerulonephritis.
COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.
Title: COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.
Atp6ap2 is critical for regulating the stored insulin pool and a balanced regulation of granule turnover is key to maintaining beta cell function and diabetes prevention
Title: Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.
PRR mediates myocardial injury, apoptosis, and the inflammatory response, likely through a PRR/extracellular signal-regulated kinase/reactive oxygen species pathway.
Title: (Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (35)

General gene information

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Markers

WI-21507 (e-PCR)
- UniSTS:82974

BE102970 (e-PCR)
- UniSTS:244413

BI276143 (e-PCR)
- UniSTS:249829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiotensin maturation	IEA Inferred from Electronic Annotation more info
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in central nervous system maturation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system maturation	ISO Inferred from Sequence Orthology more info
involved_in central nervous system maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in eye pigmentation	IEA Inferred from Electronic Annotation more info
involved_in eye pigmentation	ISO Inferred from Sequence Orthology more info
involved_in head morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in head morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lysosomal lumen acidification	IEA Inferred from Electronic Annotation more info
involved_in lysosomal lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in lysosomal lumen acidification	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transforming growth factor beta1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in rostrocaudal neural tube patterning	IEA Inferred from Electronic Annotation more info
involved_in rostrocaudal neural tube patterning	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle lumen acidification	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle lumen acidification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendritic spine membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	ISO Inferred from Sequence Orthology more info
part_of vacuolar proton-transporting V-type ATPase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: renin receptor

Names: ATPase, H(+)-transporting, lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal accessory protein 2; renin/prorenin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.