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calr3a calreticulin 3a [ Danio rerio (zebrafish) ]

Gene ID: 30248, updated on 9-Dec-2024

Summary

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Official Symbol
calr3aprovided by ZNC
Official Full Name
calreticulin 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000208-17
See related
Ensembl:ENSDARG00000103979 AllianceGenome:ZFIN:ZDB-GENE-000208-17
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
calr; zgc:85636
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including axis; cardiovascular system; hatching gland; periderm; and polster. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See calr3a in Genome Data Viewer
Location:
chromosome: 22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (4762478..4769054, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (4378103..4384679, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene RAD23 homolog A, nucleotide excision repair protein b Neighboring gene LOC100332737 Neighboring gene novel protein with Immunoglobulin V-set domains

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Floor plate develops upon depletion of tiggy-winkle and sonic hedgehog. Etheridge LA, et al. Genesis, 2001 Jul. PMID 11477699
  2. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Lim KH, et al. Blood Cancer J, 2016 Oct 7. PMID 27716741, Free PMC Article
  3. Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish. Sun Y, et al. Dis Model Mech, 2017 Oct 1. PMID 28801532, Free PMC Article
  4. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
  5. Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. Thakur PC, et al. Hepatology, 2011 Aug. PMID 21488074, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calreticulin 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131047.2 → NP_571122.2  calreticulin 3a precursor

    Status: VALIDATED

    Source sequence(s)
    CR751224, CU570881
    UniProtKB/TrEMBL
    A0A8M1PB70, Q6PE26
    Related
    ENSDARP00000130666.1, ENSDART00000165235.2
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    4762478..4769054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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