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Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302421, updated on 27-Nov-2024

Summary

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Official Symbol
Gdpd2provided by RGD
Official Full Name
glycerophosphodiester phosphodiesterase domain containing 2provided by RGD
Primary source
RGD:1560780
See related
EnsemblRapid:ENSRNOG00000002800 AllianceGenome:RGD:1560780
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560780
Summary
Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within actin filament organization and positive regulation of osteoblast differentiation. Predicted to be located in actin filament and lamellipodium. Predicted to be active in plasma membrane. Orthologous to human GDPD2 (glycerophosphodiester phosphodiesterase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 175.3), Brain (RPKM 17.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Gdpd2 in Genome Data Viewer
Location:
Xq22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (69866395..69875419)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (65826273..65835361)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70563381..70572295)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099344 Neighboring gene kinesin family member 4A Neighboring gene transfer RNA phenylalanine (anticodon GAA) 8 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene testis expressed 11 Neighboring gene sarcoglycan, beta, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation. Yanaka N, et al. J Biol Chem, 2003 Oct 31. PMID 12933806
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycerophosphodiester phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycerophosphoinositol inositolphosphodiesterase GDPD2
NP_001100414.1
XP_006257126.1
XP_038955521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106944.1 → NP_001100414.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

    See identical proteins and their annotated locations for NP_001100414.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473966
    UniProtKB/TrEMBL
    A6IQ87, D3Z9K9
    Related
    ENSRNOP00000003772.3, ENSRNOT00000003772.7
    Conserved Domains (1) summary
    cl14615
    Location:198 → 499
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    69866395..69875419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099593.2 → XP_038955521.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1

    UniProtKB/TrEMBL
    A6IQ87, D3Z9K9
    Conserved Domains (1) summary
    cl14615
    Location:198 → 499
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  2. XM_006257064.5 → XP_006257126.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1

    See identical proteins and their annotated locations for XP_006257126.1

    UniProtKB/TrEMBL
    A6IQ87, D3Z9K9
    Conserved Domains (1) summary
    cl14615
    Location:198 → 499
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
Nucleotide Protein Strain
Heading Accession and Version

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