U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

htt huntingtin [ Danio rerio (zebrafish) ]

Gene ID: 30214, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
httprovided by ZNC
Official Full Name
huntingtinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-131
See related
Ensembl:ENSDARG00000052866 AllianceGenome:ZFIN:ZDB-GENE-990415-131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hd; ZHD
Summary
Acts upstream of or within several processes, including chordate embryonic development; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in cytoplasm and nucleus. Is expressed in brain; head; intermediate cell mass of mesoderm; and post-vent region. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See htt in Genome Data Viewer
Location:
chromosome: 1
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (41293962..41374420, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (40591177..40671671, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein associated protein 1 Neighboring gene docking protein 7b Neighboring gene regulator of G protein signaling 12b Neighboring gene si:ch211-89o9.4 Neighboring gene transfer RNA glutamic acid (anticodon CUC)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Huntingtin confers fitness but is not embryonically essential in zebrafish development. Sidik H, et al. Dev Biol, 2020 Feb 1. PMID 31682806
  2. Characterization of the Huntington's disease (HD) gene homologue in the zebrafish Danio rerio. Karlovich CA, et al. Gene, 1998 Sep 14. PMID 9795179
  3. Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models. Conforti P, et al. J Neurochem, 2013 Oct. PMID 23800350
  4. Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. Diekmann H, et al. J Neurosci, 2009 Feb 4. PMID 19193881, Free PMC Article
  5. Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Lumsden AL, et al. Hum Mol Genet, 2007 Aug 15. PMID 17567778

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Huntingtin confers fitness but is not embryonically essential in zebrafish development.
    Title: Huntingtin confers fitness but is not embryonically essential in zebrafish development.
  2. These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types.
    Title: Selective neuronal requirement for huntingtin in the developing zebrafish.
  3. In vivo, huntingtin deficient zebrafish had a severe phenotype and reduced expression of LXR reg'd genes. An LXR agonist partially rescued the phenotype and expression of LXR target genes in huntingtin deficient zebrafish during early development.
    Title: Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.
  4. the effects of Htt deficiency in early zebrafish development.
    Title: Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within anterior neural plate formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuromast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within olfactory placode development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of brain-derived neurotrophic factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
huntingtin
Names
etID309952.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131018.1 → NP_571093.1  huntingtin

    See identical proteins and their annotated locations for NP_571093.1

    Status: PROVISIONAL

    Source sequence(s)
    AF052602
    UniProtKB/TrEMBL
    O42269
    Related
    ENSDARP00000069263.3, ENSDART00000074777.5
    Conserved Domains (2) summary
    pfam12372
    Location:1499 → 1525
    DUF3652; Huntingtin protein region
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    41293962..41374420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292973.4 → XP_009291248.1  huntingtin isoform X4

    UniProtKB/TrEMBL
    A0A8M3AIU2
    Conserved Domains (2) summary
    pfam12372
    Location:1484 → 1510
    DUF3652; Huntingtin protein region
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]

  2. XM_009292971.4 → XP_009291246.1  huntingtin isoform X3

    UniProtKB/TrEMBL
    A0A8M3AU50
    Conserved Domains (2) summary
    pfam12372
    Location:1547 → 1573
    DUF3652; Huntingtin protein region
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]

  3. XM_005160016.5 → XP_005160073.1  huntingtin isoform X5

    UniProtKB/TrEMBL
    A0A8M2B6V6
    Conserved Domains (2) summary
    pfam12372
    Location:1499 → 1525
    DUF3652; Huntingtin protein region
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]

  4. XM_009292966.4 → XP_009291241.1  huntingtin isoform X2

    UniProtKB/TrEMBL
    A0A8M3B295
    Conserved Domains (2) summary
    pfam12372
    Location:1562 → 1588
    DUF3652; Huntingtin protein region
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]

  5. XM_009292964.4 → XP_009291239.1  huntingtin isoform X1

    UniProtKB/TrEMBL
    A0A8M3AIT6
    Conserved Domains (2) summary
    pfam12372
    Location:1562 → 1588
    DUF3652; Huntingtin protein region
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools