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Amn1 antagonist of mitotic exit network 1 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 302032, updated on 27-Nov-2024

Summary

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Official Symbol
Amn1provided by RGD
Official Full Name
antagonist of mitotic exit network 1 homologprovided by RGD
Primary source
RGD:1308119
See related
EnsemblRapid:ENSRNOG00000036917 AllianceGenome:RGD:1308119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308119
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in microvillus membrane. Orthologous to human AMN1 (antagonist of mitotic exit network 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 100.6), Spleen (RPKM 70.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amn1 in Genome Data Viewer
Location:
4q44
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183886469..183913411, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (182155140..182182085, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183670589..183697531, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene U6 spliceosomal RNA Neighboring gene mesoderm specific transcript, pseudogene 1 Neighboring gene electron transfer flavoprotein subunit beta lysine methyltransferase Neighboring gene adenosylhomocysteinase-like Neighboring gene basic transcription factor 3, pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105998

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein AMN1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008333.2 → NP_001008334.2  protein AMN1 homolog

    See identical proteins and their annotated locations for NP_001008334.2

    Status: VALIDATED

    Source sequence(s)
    BC086357, BG672304
    UniProtKB/Swiss-Prot
    Q5U201
    UniProtKB/TrEMBL
    A0A8L2QRD5, A6IN73
    Related
    ENSRNOP00000089244.2, ENSRNOT00000117439.2
    Conserved Domains (2) summary
    cd09293
    Location:37 → 257
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:63 → 86
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    183886469..183913411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237700.3 → XP_006237762.1  protein AMN1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABJ0, A0A8L2QRD5
    Conserved Domains (2) summary
    cd09293
    Location:1 → 214
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:20 → 43
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U201.2 GenPept UniProtKB/Swiss-Prot:Q5U201

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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