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alcama activated leukocyte cell adhesion molecule a [ Danio rerio (zebrafish) ]

Gene ID: 30194, updated on 9-Dec-2024

Summary

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Official Symbol
alcamaprovided by ZNC
Official Full Name
activated leukocyte cell adhesion molecule aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-30
See related
Ensembl:ENSDARG00000026531 AllianceGenome:ZFIN:ZDB-GENE-990415-30
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
alcam; cd166; DM-GRASP
Summary
Enables identical protein binding activity. Involved in several processes, including cartilage morphogenesis; neural crest cell differentiation; and positive regulation of cell morphogenesis. Acts upstream of or within axonogenesis; embryonic organ morphogenesis; and retina morphogenesis in camera-type eye. Located in axon. Is expressed in several structures, including digestive system; immature eye; musculature system; nervous system; and pericardial region. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See alcama in Genome Data Viewer
Location:
chromosome: 10
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (28731749..28835782, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (28845128..28949151, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene Cbl proto-oncogene B, E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC110440072 Neighboring gene uncharacterized LOC103911755 Neighboring gene uncharacterized LOC137496546 Neighboring gene si:ch211-103f14.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatiotemporal pattern of retinal ganglion cell differentiation revealed by the expression of neurolin in embryonic zebrafish. Laessing U, et al. J Neurobiol, 1996 Jan. PMID 8748372
  2. Movement disorder and neuromuscular change in zebrafish embryos after exposure to caffeine. Chen YH, et al. Neurotoxicol Teratol, 2008 Sep-Oct. PMID 18508234
  3. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. Fausett BV, et al. J Neurosci, 2006 Jun 7. PMID 16763038, Free PMC Article
  4. Polarization and orientation of retinal ganglion cells in vivo. Zolessi FR, et al. Neural Dev, 2006 Oct 13. PMID 17147778, Free PMC Article
  5. Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish. Sakai JA, et al. Development, 2006 Mar. PMID 16467361

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.
    Title: Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.
  2. Results suggest that the zebrafish Neurolin-a and -b paralogs are involved in distinct steps of retinotectal development.
    Title: Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding.
  3. Muscle pioneer fibres express neurolin but not NLCAM at high level.
    Title: Comparison of neurolin (ALCAM) and neurolin-like cell adhesion molecule (NLCAM) expression in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cartilage morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD166 antigen homolog A
Names
DM-GRASP homolog
neurolin
neurolin-a
zn5 / zn-5 antigen
zn8 / zn-8 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131000.1 → NP_571075.1  CD166 antigen homolog A precursor

    See identical proteins and their annotated locations for NP_571075.1

    Status: PROVISIONAL

    Source sequence(s)
    L25273
    UniProtKB/Swiss-Prot
    Q90460, Q90480
    Related
    ENSDARP00000152888.1, ENSDART00000192220.1
    Conserved Domains (7) summary
    smart00406
    Location:306 → 387
    IGv; Immunoglobulin V-Type
    smart00410
    Location:254 → 322
    IG_like; Immunoglobulin like
    pfam07679
    Location:406 → 485
    I-set; Immunoglobulin I-set domain
    pfam01034
    Location:506 → 554
    Syndecan; Syndecan domain
    pfam08205
    Location:134 → 221
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:247 → 323
    Ig_2; Immunoglobulin domain
    cl11960
    Location:424 → 477
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    28731749..28835782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172635.5 → XP_005172692.1  CD166 antigen homolog A isoform X1

    UniProtKB/TrEMBL
    A0A2R8PV55, A0A8M2BJY9
    Related
    ENSDARP00000144664.1, ENSDART00000188436.1
    Conserved Domains (7) summary
    smart00406
    Location:306 → 387
    IGv; Immunoglobulin V-Type
    smart00410
    Location:254 → 322
    IG_like; Immunoglobulin like
    pfam07679
    Location:406 → 485
    I-set; Immunoglobulin I-set domain
    pfam01034
    Location:497 → 545
    Syndecan; Syndecan domain
    pfam08205
    Location:134 → 221
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:247 → 323
    Ig_2; Immunoglobulin domain
    cl11960
    Location:424 → 477
    Ig; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395290.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    239509..268579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90460.1 GenPept UniProtKB/Swiss-Prot:Q90460

Gene LinkOut

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