U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tyw5 tRNA-yW synthesizing protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301419, updated on 27-Nov-2024

Summary

Official Symbol
Tyw5provided by RGD
Official Full Name
tRNA-yW synthesizing protein 5provided by RGD
Primary source
RGD:1311269
See related
EnsemblRapid:ENSRNOG00000010100 AllianceGenome:RGD:1311269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C2orf60; RGD1311269
Summary
Predicted to enable several functions, including iron ion binding activity; protein homodimerization activity; and tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity. Predicted to be involved in wybutosine biosynthetic process. Orthologous to human TYW5 (tRNA-yW synthesizing protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 61.1), Heart (RPKM 53.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tyw5 in Genome Data Viewer
Location:
9q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (66455364..66473446, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (58961100..58979188, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (64077841..64096265, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094688 Neighboring gene uncharacterized LOC102549484 Neighboring gene similar to human chromosome 2 open reading frame 69 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene matrix AAA peptidase interacting protein 1 Neighboring gene ribosomal protein L6, pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General protein information

Preferred Names
tRNA wybutosine-synthesizing protein 5
NP_001163944.1
XP_006244972.1
XP_017451845.1
XP_017451846.1
XP_038939226.1
XP_038939227.1
XP_063123012.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170473.1NP_001163944.1  tRNA wybutosine-synthesizing protein 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    BC158619, CK845177, FM112098
    UniProtKB/TrEMBL
    D3ZY75
    Related
    ENSRNOP00000013502.6, ENSRNOT00000013502.8
    Conserved Domains (1) summary
    pfam13621
    Location:17264
    Cupin_8; Cupin-like domain

RNA

  1. NR_033170.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at an internal exon compared to variant 1, which causes a frame-shift. It is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC158619, CK845177

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    66455364..66473446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244910.4XP_006244972.1  tRNA wybutosine-synthesizing protein 5 isoform X2

    Conserved Domains (1) summary
    pfam13621
    Location:17218
    Cupin_8; Cupin-like domain
  2. XM_039083298.2XP_038939226.1  tRNA wybutosine-synthesizing protein 5 isoform X4

    Conserved Domains (1) summary
    cl40423
    Location:15219
    cupin_RmlC-like; RmlC-like cupin superfamily
  3. XM_063266942.1XP_063123012.1  tRNA wybutosine-synthesizing protein 5 isoform X5

    UniProtKB/TrEMBL
    A6IP36
  4. XM_017596357.3XP_017451846.1  tRNA wybutosine-synthesizing protein 5 isoform X3

    Related
    ENSRNOP00000103536.1, ENSRNOT00000147066.1
  5. XM_017596356.3XP_017451845.1  tRNA wybutosine-synthesizing protein 5 isoform X1

    Related
    ENSRNOP00000099526.1, ENSRNOT00000153755.1
  6. XM_039083299.1XP_038939227.1  tRNA wybutosine-synthesizing protein 5 isoform X5

    UniProtKB/TrEMBL
    A6IP36
    Conserved Domains (1) summary
    cl40423
    Location:13120
    cupin_RmlC-like; RmlC-like cupin superfamily