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Plcl2 phospholipase C-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301173, updated on 14-Nov-2024

Summary

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Symbol
Plcl2provided by RGD
Full Name
phospholipase C-like 2provided by RGD
Primary source
RGD:1305941
See related
EnsemblRapid:ENSRNOG00000013368 AllianceGenome:RGD:1305941
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GABA receptor binding activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of GABAergic synaptic transmission. Predicted to act upstream of or within B cell proliferation involved in immune response; B-1a B cell differentiation; and negative regulation of B cell receptor signaling pathway. Orthologous to human PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 342.9), Brain (RPKM 252.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plcl2 in Genome Data Viewer
Location:
9q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (3529117..3713712)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (3292564..3477009)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (1782536..1984654, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094622 Neighboring gene uncharacterized LOC120094621 Neighboring gene uncharacterized LOC134480316 Neighboring gene uncharacterized LOC134480471 Neighboring gene TBC1 domain family, member 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1, pseudogene 1 Neighboring gene ribosomal protein L10, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Takenaka K, et al. Mol Cell Biol, 2003 Oct. PMID 14517301, Free PMC Article
  2. Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes. Oue K, et al. J Biol Chem, 2016 Feb 19. PMID 26706316, Free PMC Article
  3. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. Kanematsu T, et al. J Biol Chem, 2006 Aug 4. PMID 16754670
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within B-1a B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inactive phospholipase C-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106880.1 → NP_001100350.1  inactive phospholipase C-like protein 2

    See identical proteins and their annotated locations for NP_001100350.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474081
    UniProtKB/TrEMBL
    A0A8I5ZYT1, A6KPP0
    Related
    ENSRNOP00000108323.1, ENSRNOT00000147406.1
    Conserved Domains (6) summary
    cd00275
    Location:627 → 755
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:299 → 595
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    PLN02228
    Location:209 → 757
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:17 → 125
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam00169
    Location:19 → 125
    PH; PH domain
    pfam09279
    Location:217 → 299
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    3529117..3713712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083165.2 → XP_038939093.1  inactive phospholipase C-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYT1, F1M324
    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

  2. XM_039083164.2 → XP_038939092.1  inactive phospholipase C-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYT1, F1M324
    Related
    ENSRNOP00000018146.7, ENSRNOT00000018146.9
    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

RNA

  1. XR_010054577.1 RNA Sequence

  2. XR_010054576.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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