Efhb EF hand domain family, member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efhbprovided by RGD
Official Full Name: EF hand domain family, member Bprovided by RGD
Primary source: RGD:1566407
See related: EnsemblRapid:ENSRNOG00000012618 AllianceGenome:RGD:1566407
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566407
Summary: Predicted to enable calcium ion sensor activity. Predicted to be involved in regulation of calcineurin-NFAT signaling cascade and regulation of store-operated calcium entry. Predicted to be located in axonemal microtubule. Predicted to be active in axonemal A tubule inner sheath. Orthologous to human EFHB (EF-hand domain family member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 50.6) and Lung (RPKM 15.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (6608791..6680104, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (6372191..6441678, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47988..120800)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EF-hand domain-containing family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106879.1 → NP_001100349.1 EF-hand domain-containing family member B

See identical proteins and their annotated locations for NP_001100349.1

Status: PROVISIONAL

Source sequence(s)

CH474184

UniProtKB/TrEMBL

A6KUI0, A6KUI1

Related

ENSRNOP00000016911.7, ENSRNOT00000016911.8

Conserved Domains (2) summary

cd00051
Location:585 → 646

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:585 → 645

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

6608791..6680104 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266839.1 → XP_063122909.1 EF-hand domain-containing family member B isoform X3
XM_039083162.1 → XP_038939090.1 EF-hand domain-containing family member B isoform X3

Conserved Domains (1) summary

pfam13499
Location:278 → 342

EF-hand_7; EF-hand domain pair
XM_039083161.1 → XP_038939089.1 EF-hand domain-containing family member B isoform X2

Conserved Domains (1) summary

pfam13499
Location:304 → 368

EF-hand_7; EF-hand domain pair
XM_063266838.1 → XP_063122908.1 EF-hand domain-containing family member B isoform X1