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Rnf7 ring finger protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300948, updated on 27-Nov-2024

Summary

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Official Symbol
Rnf7provided by RGD
Official Full Name
ring finger protein 7provided by RGD
Primary source
RGD:1311048
See related
EnsemblRapid:ENSRNOG00000011663 AllianceGenome:RGD:1311048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NEDD8 ligase activity; cullin family protein binding activity; and ubiquitin protein ligase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein modification by small protein conjugation. Predicted to act upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; brain development; and intrinsic apoptotic signaling pathway in response to oxidative stress. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RNF7 (ring finger protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 294.7), Heart (RPKM 213.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf7 in Genome Data Viewer
Location:
8q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105918395..105927643, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97038845..97048080, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104326719..104336098, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 21 Neighboring gene uncharacterized LOC134480217 Neighboring gene uncharacterized LOC120094236 Neighboring gene leucine rich repeat containing 78 Neighboring gene uncharacterized LOC120094237

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell Autophagy via Upregulation of THBS1 and Inactivation of the PI3K/Akt Signaling Pathway in a Rat Sepsis Model. Lei Y, et al. Infect Immun, 2023 Apr 18. PMID 36920202, Free PMC Article
  2. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Duan H, et al. Mol Cell Biol, 1999 Apr. PMID 10082581, Free PMC Article
  3. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Ohta T, et al. Mol Cell, 1999 Apr. PMID 10230407
  4. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Huang DT, et al. Mol Cell, 2009 Feb 27. PMID 19250909, Free PMC Article
  5. The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Tron AE, et al. Mol Cell, 2012 Apr 13. PMID 22405651, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell Autophagy via Upregulation of THBS1 and Inactivation of the PI3K/Akt Signaling Pathway in a Rat Sepsis Model.
    Title: RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell Autophagy via Upregulation of THBS1 and Inactivation of the PI3K/Akt Signaling Pathway in a Rat Sepsis Model.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NEDD8 ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within radial glia guided migration of Purkinje cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_negative_effect reelin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING-box protein 2
NP_001100318.1
XP_008764711.1
XP_063121293.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106848.1 → NP_001100318.1  RING-box protein 2

    See identical proteins and their annotated locations for NP_001100318.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A0A8I6AAL1, A6I280, D3Z8P1
    Related
    ENSRNOP00000015821.6, ENSRNOT00000015821.7
    Conserved Domains (1) summary
    cd16466
    Location:47 → 106
    RING-H2_RBX2; RING finger, H2 subclass, found in RING-box protein 2 (RBX2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    105918395..105927643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766489.4 → XP_008764711.1  RING-box protein 2 isoform X2

    Conserved Domains (1) summary
    cl17238
    Location:28 → 55
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_063265223.1 → XP_063121293.1  RING-box protein 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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