Morf4l1 mortality factor 4 like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Morf4l1provided by RGD
Official Full Name: mortality factor 4 like 1provided by RGD
Primary source: RGD:1307938
See related: EnsemblRapid:ENSRNOG00000058412 AllianceGenome:RGD:1307938
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Predicted to act upstream of or within fibroblast proliferation. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex; Sin3-type complex; and nucleosome. Orthologous to human MORF4L1 (mortality factor 4 like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 327.0), Testes (RPKM 311.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (99522801..99544432, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (90642988..90664518, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (97473454..97494974, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of NuA4 histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Sin3-type complex	IEA Inferred from Electronic Annotation more info
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info
part_of Sin3-type complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mortality factor 4-like protein 1

Names: MORF-related gene 15 protein; transcription factor-like protein MRG15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011999.2 → NP_001011999.1 mortality factor 4-like protein 1

See identical proteins and their annotated locations for NP_001011999.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q6AYU1

UniProtKB/TrEMBL

A0A8I6ANZ2, A6I217

Related

ENSRNOP00000095145.2, ENSRNOT00000103722.2

Conserved Domains (2) summary

pfam05712
Location:135 → 309

MRG; MRG

pfam11717
Location:11 → 64

Tudor-knot; RNA binding activity-knot of a chromodomain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

99522801..99544432 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766445.4 → XP_008764667.1 mortality factor 4-like protein 1 isoform X3

See identical proteins and their annotated locations for XP_008764667.1

UniProtKB/TrEMBL

A0A8I6A2P7, A0A8I6ANZ2, A6I218

Related

ENSRNOP00000086652.1, ENSRNOT00000094232.2

Conserved Domains (2) summary

pfam05712
Location:174 → 348

MRG; MRG

pfam11717
Location:11 → 103

Tudor-knot; RNA binding activity-knot of a chromodomain
XM_063265204.1 → XP_063121274.1 mortality factor 4-like protein 1 isoform X7

UniProtKB/TrEMBL

A0A8I6ANZ2
XM_017595579.3 → XP_017451068.1 mortality factor 4-like protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6ANZ2
XM_063265203.1 → XP_063121273.1 mortality factor 4-like protein 1 isoform X6

UniProtKB/TrEMBL

A0A8I6ANZ2
XM_063265202.1 → XP_063121272.1 mortality factor 4-like protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I6ANZ2
XM_063265201.1 → XP_063121271.1 mortality factor 4-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6ANZ2
XM_063265200.1 → XP_063121270.1 mortality factor 4-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ANZ2
XM_063265205.1 → XP_063121275.1 mortality factor 4-like protein 1 isoform X8
XM_063265206.1 → XP_063121276.1 mortality factor 4-like protein 1 isoform X8