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Pclaf PCNA clamp associated factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 300795, updated on 27-Nov-2024

Summary

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Official Symbol
Pclafprovided by RGD
Official Full Name
PCNA clamp associated factorprovided by RGD
Primary source
RGD:1303041
See related
EnsemblRapid:ENSRNOG00000067723 AllianceGenome:RGD:1303041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Paf; PAF15; Ns5atp9
Summary
Predicted to enable chromatin binding activity and molecular adaptor activity. Predicted to be involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Predicted to be located in centrosome and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to human PCLAF (PCNA clamp associated factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 449.4), Spleen (RPKM 262.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pclaf in Genome Data Viewer
Location:
8q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75311028..75328108)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66420606..66432994)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71514281..71526182)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693122 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene U6 spliceosomal RNA Neighboring gene casein kinase 1, gamma 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. KIAA0101 interacts with BRCA1 and regulates centrosome number. Kais Z, et al. Mol Cancer Res, 2011 Aug. PMID 21673012, Free PMC Article
  2. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Emanuele MJ, et al. Proc Natl Acad Sci U S A, 2011 Jun 14. PMID 21628590, Free PMC Article
  3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
PCNA-associated factor
Names
HCV NS5A-transactivated protein 9 homolog
NS5A (hepatitis C virus) transactivated protein 9
PCNA-associated factor of 15 kDa
p15PAF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201418.2 → NP_958821.1  PCNA-associated factor

    See identical proteins and their annotated locations for NP_958821.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q6RIA2
    UniProtKB/TrEMBL
    A6J5G6
    Related
    ENSRNOP00000091479.2, ENSRNOT00000112544.2
    Conserved Domains (1) summary
    pfam15715
    Location:1 → 100
    PAF; PCNA-associated factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    75311028..75328108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265162.1 → XP_063121232.1  PCNA-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q6RIA2
    UniProtKB/TrEMBL
    A6J5G6

  2. XM_063265161.1 → XP_063121231.1  PCNA-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q6RIA2
    UniProtKB/TrEMBL
    A6J5G6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RIA2.1 GenPept UniProtKB/Swiss-Prot:Q6RIA2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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